| Tyler Adams | MID | Out indefinitely | Hamstring | Hamstring | Apr 11 |
| Justin Kluivert | F | Out indefinitely | Knock | Knock | Feb 13 |
| Marcus Tavernier | MID | Out indefinitely | None | Tavernier is injured | Dec 15 |
| Luis Sinisterra | F | Out | Knock | Knock | Feb 25 |
| Marcos Senesi | DEF | Out indefinitely | Knock | Knock | Sep 20 |
| Alex Scott | MID | Out indefinitely | None | Scott is injured | Oct 25 |
| Kai Havertz | F | Out indefinitely | Illness | Illness | Apr 3 |
| Neto | GK | Out | Thigh Muscle Rupture | Thigh Muscle Rupture | Jan 7 |
| Thomas Partey | MID | Out | Back Injury | Back Injury | Feb 25 |
| Oleksandr Zinchenko | DEF | Doubtful | None | Zinchenko is doubtful | Dec 13 |
| Martin Odegaard | MID | Out indefinitely | Virus | Virus | Jan 24 |
| Ben White | DEF | Out indefinitely | None | White is injured | Nov 22 |
| Gabriel Magalhaes | DEF | Out indefinitely | Hamstring | Hamstring | May 17 |
| Takehiro Tomiyasu | DEF | Out indefinitely | Knee Injury | Knee Injury | Apr 11 |
| William Saliba | DEF | Out indefinitely | Back Injury | Back Injury | Apr 11 |
| Diego Carlos | DEF | Out | Calf/Shin Injury | Calf/Shin Injury | Mar 13 |
| Boubacar Kamara | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 11 |
| Pau Torres | DEF | Out indefinitely | Knock | Knock | Apr 4 |
| Leon Bailey | MID | Out | Ankle/Foot Injury | Ankle/Foot Injury | May 15 |
| Emiliano Buendia | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Dec 27 |
| Jacob Ramsey | MID | Out indefinitely | None | Ramsey is injured | Nov 22 |
| Josh Da Silva | MID | Out indefinitely | None | Da Silva is injured | Aug 17 |
| Yoane Wissa | MID | Out indefinitely | Ankle Fracture | Ankle Fracture | Nov 29 |
| Kristoffer Ajer | DEF | Out | Calf/Shin Injury | Calf/Shin Injury | Apr 11 |
| Mark Flekken | GK | Out indefinitely | Virus | Virus | Jan 24 |
| Mathias Jensen | MID | Out indefinitely | Knock | Knock | Aug 28 |
| Christian Norgaard | MID | Out | Calf/Shin Injury | Calf/Shin Injury | Oct 29 |
| Sepp Van den Berg | DEF | Out indefinitely | None | Van den Berg is injured | Dec 20 |
| Aaron Hickey | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 23 |
| Fabio Carvalho | MID | Out indefinitely | Thigh Muscle Rupture | Thigh Muscle Rupture | Sep 16 |
| Rico Henry | DEF | Out indefinitely | None | Henry is injured | Aug 17 |
| Ethan Pinnock | DEF | Out indefinitely | None | Pinnock is injured | Dec 20 |
| Igor Thiago | F | Out | None | Thiago is out | Dec 20 |
| Gustavo Nunes | F | Out indefinitely | None | Nunes is injured | Sep 13 |
| Danny Welbeck | F | Out indefinitely | None | Welbeck is injured | Dec 20 |
| James Milner | MID | Out indefinitely | None | Milner is injured | Oct 18 |
| Joel Veltman | DEF | Out indefinitely | Thigh Muscle Rupture | Thigh Muscle Rupture | Jan 3 |
| Solly March | MID | Out indefinitely | None | March is injured | Aug 16 |
| Pervis Estupinan | DEF | Out | Hamstring | Hamstring | Apr 21 |
| Jason Steele | GK | Out indefinitely | Back Injury | Back Injury | Feb 14 |
| Adam Webster | DEF | Out indefinitely | None | Webster is injured | Oct 18 |
| Georginio Rutter | F | Out indefinitely | Shoulder Injury | Shoulder Injury | Jul 11 |
| Jack Hinshelwood | MID | Out indefinitely | None | Hinshelwood is injured | Dec 7 |
| S. Ojo | A | Out indefinitely | Knock | Knock | Feb 25 |
| G. Madine | A | Out indefinitely | Illness | Illness | Oct 28 |
| Romaine Theodore Sawyers | MID | Out | Suspended | Suspended | Mar 3 |
| J. Philogene | MID | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Feb 7 |
| Wesley Fofana | DEF | Out | Knock | Knock | Apr 4 |
| Reece James | DEF | Out indefinitely | None | James is injured | Nov 22 |
| Mykhailo Mudryk | F | Out | None | Mudryk is out | Sep 2 |
| Marc Cucurella | DEF | Out | Suspended | Suspended | Mar 6 |
| Joao Felix | F | Doubtful | None | Felix is doubtful | Feb 10 |
| Axel Disasi | DEF | Out | Suspended | Suspended | May 1 |
| Romeo Lavia | MID | Out indefinitely | None | Lavia is injured | Dec 21 |
| Nicolas Jackson | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Mar 7 |
| Benoit Badiashile | DEF | Out indefinitely | None | Badiashile is injured | Dec 21 |
| Omari Kellyman | F | Out indefinitely | None | Kellyman is injured | Sep 13 |
| Rob Holding | DEF | Out | None | Holding is out | Nov 28 |
| Ismaila Sarr | F | Doubtful | None | Sarr is doubtful | May 18 |
| Jean-Philippe Mateta | F | Out | Suspended | Suspended | May 17 |
| Daichi Kamada | MID | Out indefinitely | Knock | Knock | Nov 11 |
| Chris Richards | DEF | Out | Knock | Knock | Apr 9 |
| Matheus Franca | MID | Out indefinitely | None | Franca is injured | Nov 1 |
| Adam Wharton | MID | Out indefinitely | None | Wharton is injured | Nov 1 |
| Ashley Young | DEF | Out indefinitely | Toe Injury | Toe Injury | Jan 17 |
| Jordan Pickford | GK | Out | Thigh Muscle Strain | Thigh Muscle Strain | Oct 1 |
| Orel Mangala | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Oct 3 |
| James Garner | MID | Out indefinitely | None | Garner is injured | Oct 18 |
| Armando Broja | F | Out | None | Broja is out | Dec 21 |
| Vitaliy Mykolenko | DEF | Out | Calf/Shin Injury | Calf/Shin Injury | May 11 |
| Dwight McNeil | MID | Doubtful | None | McNeil is doubtful | Dec 21 |
| Tim Iroegbunam | MID | Out indefinitely | None | Iroegbunam is injured | Oct 18 |
| Harrison Reed | MID | Out indefinitely | None | Reed is injured | Nov 22 |
| Bernd Leno | GK | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | Dec 20 |
| Issa Diop | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jul 4 |
| Sasa Lukic | MID | Out | Hamstring | Hamstring | Apr 17 |
| Kenny Tete | DEF | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Dec 27 |
| Timothy Castagne | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Mar 21 |
| Joachim Andersen | DEF | Out | Calf/Shin Injury | Calf/Shin Injury | Feb 11 |
| Carlos Vinicius | F | Out indefinitely | Hamstring | Hamstring | Aug 28 |
| Reiss Nelson | F | Out indefinitely | None | Nelson is injured | Dec 7 |
| Y. Sanogo | A | Out | Shoulder Injury | Shoulder Injury | Feb 15 |
| M. Lowton | DEF | Out indefinitely | Knee Injury | Knee Injury | Oct 26 |
| Jason Puncheon | MID | Out indefinitely | PCL Knee Ligament Injury | PCL Knee Ligament Injury | May 28 |
| Fraizer Campbell | A | Out | Suspended | Suspended | Nov 18 |
| O. Niasse | A | Out | Suspended | Suspended | Nov 29 |
| A. King | MID | Out indefinitely | Hamstring | Hamstring | Aug 14 |
| Joel Castro | GK | Out indefinitely | Back Injury | Back Injury | Nov 21 |
| I. Mbenza | A | Out indefinitely | Knock | Knock | Feb 16 |
| A. Knockaert | MID | Out | Suspended | Suspended | Apr 7 |
| Michael Hefele | DEF | Out indefinitely | Cartilage Knee Injury | Cartilage Knee Injury | Aug 9 |
| Tom Smith | DEF | Out | Suspended | Suspended | Mar 9 |
| Jonathan Hogg | MID | Out | Suspended | Suspended | Jan 18 |
| C. Quaner | A | Out | Hamstring | Hamstring | Jan 20 |
| Daniel Williams | MID | Out | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Mar 30 |
| A. Pritchard | MID | Out indefinitely | Foot Injury | Foot Injury | Mar 12 |
| Pipa Ávila | DEF | Out indefinitely | Knock | Knock | Jul 17 |
| K. Ahearne-Grant | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 27 |
| Marc Pugh | MID | Out indefinitely | Hamstring | Hamstring | Sep 24 |
| Curtis Davies | DEF | Out indefinitely | Hamstring | Hamstring | Mar 7 |
| Brian Lenihan | DEF | Out indefinitely | Knee Injury | Knee Injury | Mar 7 |
| Moses Odubajo | DEF | Out | Knee Injury | Knee Injury | Mar 7 |
| Ryan Mason | MID | Out indefinitely | Head Injury | Head Injury | Mar 7 |
| David Meyler | MID | Out indefinitely | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Jun 8 |
| Sebastian Larsson | MID | Out | Suspended | Suspended | Feb 20 |
| Adama Noss Traoré | MID | Out | Medical Condition | Medical Condition | Feb 29 |
| Evandro Goebel | MID | Out | Groin Strain | Groin Strain | May 31 |
| D. Pelkas | MID | Out indefinitely | Foot Injury | Foot Injury | May 24 |
| O. Tufan | MID | Out indefinitely | Knock | Knock | Feb 18 |
| A. Connolly | A | Out | Chest Injury | Chest Injury | Apr 13 |
| J. Magennis | A | Out | Suspended | Suspended | Nov 24 |
| George Moncur | MID | Out | Suspended | Suspended | Aug 28 |
| Axel Tuanzebe | DEF | Out indefinitely | None | Tuanzebe is injured | Dec 2 |
| Chiedozie Ogbene | F | Out indefinitely | None | Ogbene is injured | Nov 1 |
| Janoi Donacien | DEF | Out indefinitely | None | Donacien is injured | Aug 16 |
| George Hirst | F | Out indefinitely | None | Hirst is injured | Nov 23 |
| Rodrigo Moreno | F | Out | Ankle/Foot Injury | Ankle/Foot Injury | Mar 13 |
| Tyler Roberts | F | Out | Thigh Muscle Rupture | Thigh Muscle Rupture | May 23 |
| Junior Firpo | DEF | Out | Knee Injury | Knee Injury | Sep 3 |
| Joe Gelhardt | F | Out | Ankle Fracture | Ankle Fracture | Jan 24 |
| Leo Fuhr Hjelde | DEF | Out | Knock | Knock | Oct 29 |
| Sonny Tufail Perkins | MID | Out | Ankle/Foot Injury | Ankle/Foot Injury | Mar 11 |
| Jannik Vestergaard | DEF | Out indefinitely | Illness | Illness | Dec 27 |
| Wout Faes | DEF | Out | Suspended | Suspended | Nov 22 |
| Patson Daka | F | Out indefinitely | Hamstring | Hamstring | Jan 16 |
| Wilfred Ndidi | MID | Out indefinitely | None | Ndidi is injured | Dec 13 |
| Ricardo Pereira | DEF | Out indefinitely | None | Pereira is injured | Nov 22 |
| Mads Hermansen | GK | Out indefinitely | None | Hermansen is injured | Dec 21 |
| Alisson Alisson | GK | Out indefinitely | Virus | Virus | Jan 17 |
| Diogo Jota | F | Out | Calf/Shin Injury | Calf/Shin Injury | Feb 14 |
| Kostas Tsimikas | DEF | Out | Knock | Knock | Aug 15 |
| Ibrahima Konate | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Feb 21 |
| Luis Diaz | F | Out | Knee Injury | Knee Injury | Apr 11 |
| Darwin Nunez | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 3 |
| Conor Bradley | DEF | Out indefinitely | None | Bradley is injured | Nov 30 |
| John Stones | DEF | Out indefinitely | Hamstring | Hamstring | Mar 6 |
| Ilkay Gundogan | MID | Out | Groin Strain | Groin Strain | Feb 21 |
| Kyle Walker | DEF | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Dec 6 |
| Rodri | MID | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Oct 6 |
| Ederson | GK | Out indefinitely | Virus | Virus | Jan 15 |
| Ruben Dias | DEF | Out indefinitely | None | Dias is injured | Dec 20 |
| Erling Haaland | F | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Apr 10 |
| Oscar Bobb | MID | Out indefinitely | None | Bobb is injured | Nov 8 |
| Luke Shaw | DEF | Out indefinitely | None | Shaw is injured | Dec 6 |
| Christian Eriksen | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Feb 25 |
| Andre Onana | GK | Doubtful | None | Onana is doubtful | Nov 25 |
| Matthijs De Ligt | DEF | Out indefinitely | Knee Injury | Knee Injury | Nov 11 |
| Mason Mount | MID | Out indefinitely | None | Mount is injured | Dec 21 |
| Lisandro Martinez | DEF | Doubtful | None | Martinez is doubtful | May 11 |
| Victor Lindelof | DEF | Out indefinitely | None | Lindelof is injured | Dec 21 |
| Y. Bolasie | A | Out | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Mar 7 |
| Víctor Valdés Arribas | GK | Out indefinitely | Rib Injury | Rib Injury | May 15 |
| G. Leadbitter | MID | Out | Suspended | Suspended | Mar 10 |
| Paddy McNair | MID | Out | Suspended | Suspended | Dec 29 |
| D. Watmore | MID | Out | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Mar 7 |
| N. Taylor | DEF | Out | Hamstring | Hamstring | Jul 21 |
| M. Browne | MID | Out | Suspended | Suspended | Dec 29 |
| Z. Steffen | GK | Out indefinitely | Back Injury | Back Injury | Mar 14 |
| M. Johnson | MID | Out | Suspended | Suspended | Dec 7 |
| Callum Wilson | F | Out indefinitely | None | Wilson is injured | Dec 13 |
| Nick Pope | GK | Out indefinitely | None | Pope is injured | Dec 20 |
| Kieran Trippier | DEF | Out | Ankle/Foot Injury | Ankle/Foot Injury | May 7 |
| Emil Krafth | DEF | Out indefinitely | None | Krafth is injured | Nov 24 |
| Alexander Isak | F | Out indefinitely | Head Injury | Head Injury | Feb 13 |
| Miguel Almiron | MID | Out indefinitely | Knock | Knock | Apr 11 |
| Jamaal Lascelles | DEF | Out indefinitely | None | Lascelles is injured | Aug 16 |
| Joelinton | F | Out | Suspended | Suspended | Mar 17 |
| Bruno Guimaraes | MID | Out | Suspended | Suspended | Feb 26 |
| Alex Murphy | DEF | Doubtful | None | Murphy is doubtful | Feb 16 |
| B. Gibson | DEF | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Jun 15 |
| D. Giannoulis | DEF | Out indefinitely | Back Injury | Back Injury | Sep 19 |
| I. Hayden | MID | Out indefinitely | Knee Injury | Knee Injury | May 19 |
| J. Sørensen | MID | Out | Knee Injury | Knee Injury | Mar 2 |
| Willy Boly | DEF | Out | Hamstring | Hamstring | Apr 11 |
| Emmanuel Dennis | F | Out indefinitely | Knee Injury | Knee Injury | Jul 4 |
| Alex Moreno | F | Out indefinitely | Knock | Knock | Apr 4 |
| Harry Toffolo | DEF | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Dec 28 |
| Danilo Oliveira | MID | Out indefinitely | None | Oliveira is injured | Aug 23 |
| Ibrahim Sangare | MID | Out indefinitely | None | Sangare is injured | Sep 21 |
| Alex McCarthy | GK | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Feb 27 |
| Kyle Walker-Peters | DEF | Doubtful | None | Walker-Peters is doubtful | Dec 21 |
| Maxwel Cornet | MID | Out | Calf/Shin Injury | Calf/Shin Injury | Mar 9 |
| Aaron Ramsdale | GK | Doubtful | None | Ramsdale is doubtful | Dec 14 |
| Kamaldeen Sulemana | F | Out | Ankle/Foot Injury | Ankle/Foot Injury | Nov 14 |
| Gavin Bazunu | GK | Out indefinitely | None | Bazunu is injured | Aug 16 |
| Armel Bella-Kotchap | DEF | Out | Shoulder Injury | Shoulder Injury | Apr 10 |
| William Smallbone | MID | Out indefinitely | None | Smallbone is injured | Oct 25 |
| Ross Stewart | F | Out indefinitely | None | Stewart is injured | Oct 18 |
| S. Vokes | A | Out indefinitely | Abdominal Strain | Abdominal Strain | Nov 4 |
| P. Jagielka | DEF | Out | Suspended | Suspended | Mar 14 |
| Ashley Williams | DEF | Out indefinitely | Rib Injury | Rib Injury | Sep 28 |
| Glen Johnson | DEF | Out indefinitely | Knee Injury | Knee Injury | Feb 1 |
| R. Shawcross | DEF | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Jan 22 |
| Charlie Adam | MID | Out | Suspended | Suspended | Apr 16 |
| Stephen Ireland | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 2 |
| M. Diouf | A | Out indefinitely | Dislocated Shoulder | Dislocated Shoulder | Apr 2 |
| J. Ngoy | A | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Oct 16 |
| D. Gayle | A | Out | Knee Injury | Knee Injury | Dec 12 |
| B. Wilmot | DEF | Out indefinitely | Knee Injury | Knee Injury | Sep 3 |
| K. Hoever | DEF | Out | Thigh Muscle Rupture | Thigh Muscle Rupture | Apr 24 |
| Jan Kirchhoff | DEF | Out | Cartilage Knee Injury | Cartilage Knee Injury | Mar 7 |
| Steven Pienaar | MID | Out | Calf Muscle Strain | Calf Muscle Strain | Mar 7 |
| Victor Chinedu Anichebe | A | Out indefinitely | Knock | Knock | Jun 8 |
| Jermain Colin Defoe | A | Out | Ankle/Foot Injury | Ankle/Foot Injury | Feb 24 |
| Alim Öztürk | DEF | Out | Suspended | Suspended | May 16 |
| Max Power | MID | Out | Suspended | Suspended | Dec 7 |
| Conor McLaughlin | DEF | Out | Suspended | Suspended | Dec 2 |
| A. Diallo | A | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Nov 8 |
| Sam Clucas | MID | Out | Suspended | Suspended | Mar 30 |
| Wilfried Guemiand Bony | A | Out indefinitely | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Jun 11 |
| Kyle Naughton | DEF | Out | Suspended | Suspended | Jan 6 |
| Àngel Rangel Zaragoza | DEF | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | May 14 |
| Leon Britton | MID | Out indefinitely | Groin Strain | Groin Strain | Mar 2 |
| Jack Cork | MID | Out | Ankle/Foot Injury | Ankle/Foot Injury | Dec 27 |
| Nathan Dyer | MID | Out indefinitely | Achilles tendonitis | Achilles tendonitis | Mar 7 |
| Wayne Routledge | MID | Out | Knock | Knock | Dec 27 |
| Oliver McBurnie | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jun 7 |
| K. Palmer | MID | Out indefinitely | Hamstring | Hamstring | Nov 20 |
| Cyrus Sylvester Frederick Christie | DEF | Out | Knock | Knock | Feb 9 |
| J. Bidwell | DEF | Out | Suspended | Suspended | Sep 30 |
| J. Piroe | A | Out indefinitely | Virus | Virus | Dec 7 |
| Fraser Forster | GK | Out | Back Injury | Back Injury | May 31 |
| Ben Davies | DEF | Out indefinitely | None | Davies is injured | Dec 7 |
| Timo Werner | F | Doubtful | None | Werner is doubtful | Dec 21 |
| Richarlison | F | Out indefinitely | None | Richarlison is injured | Nov 9 |
| Cristian Romero | DEF | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Dec 6 |
| Dejan Kulusevski | MID | Out indefinitely | Hamstring | Hamstring | Nov 10 |
| Micky Van de Ven | DEF | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | May 2 |
| D. Gosling | MID | Out | Illness | Illness | Sep 11 |
| Tom Cleverley | MID | Out | Rib Injury | Rib Injury | May 22 |
| B. Hamer | GK | Out indefinitely | Knock | Knock | Jun 10 |
| Heurelho da Silva Gomes | GK | Out | Back Injury | Back Injury | Feb 24 |
| Miguel Ángel Britos Cabrera | DEF | Out indefinitely | Wisdom Teeth | Wisdom Teeth | Jun 5 |
| Craig Cathcart | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Sep 28 |
| J. Holebas | DEF | Out indefinitely | Foot Injury | Foot Injury | Jun 22 |
| Daryl Janmaat | DEF | Out indefinitely | Knee Injury | Knee Injury | Oct 15 |
| Christian Kabasele | DEF | Out | Knock | Knock | Jan 1 |
| Younes Kaboul | DEF | Out indefinitely | Metatarsal Fracture | Metatarsal Fracture | Sep 24 |
| T. Deeney | A | Out indefinitely | Knee Injury | Knee Injury | Nov 8 |
| Ben Foster | GK | Out | Groin/Pelvis Injury | Groin/Pelvis Injury | Jan 15 |
| G. Murray | A | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Feb 27 |
| H. Choudhury | MID | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | May 23 |
| R. Elliot | GK | Out indefinitely | Knock | Knock | Feb 24 |
| O. Etebo | MID | Out indefinitely | Knock | Knock | Jun 30 |
| K. Hause | DEF | Out indefinitely | Knee Injury | Knee Injury | Apr 11 |
| B. Sako | A | Out | Groin/Pelvis Injury | Groin/Pelvis Injury | Feb 14 |
| Jake Livermore | MID | Out | Suspended | Suspended | Dec 29 |
| Gareth McAuley | DEF | Out indefinitely | Illness | Illness | Feb 1 |
| James Morrison | MID | Out indefinitely | Achilles tendonitis | Achilles tendonitis | Jun 4 |
| Matt Phillips | MID | Out indefinitely | Virus | Virus | Jan 27 |
| Hal Robson-Kanu | MID | Out indefinitely | Arm/Elbow injury | Arm/Elbow injury | Jan 18 |
| G. Diangana | MID | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Feb 1 |
| A. Carroll | A | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Dec 14 |
| K. Bryan | DEF | Out | Calf/Shin Injury | Calf/Shin Injury | Dec 30 |
| Matheus Pereira | A | Out | Suspended | Suspended | Dec 27 |
| O. Yokuşlu | MID | Out indefinitely | Hamstring | Hamstring | Jan 3 |
| Kyle Bartley | DEF | Out | Calf/Shin Injury | Calf/Shin Injury | Jan 2 |
| K. Zohorè | A | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Oct 18 |
| Michail Antonio | F | Out indefinitely | None | Antonio is injured | Dec 20 |
| Alphonse Areola | GK | Out indefinitely | Hamstring | Hamstring | Feb 20 |
| Carlos Soler | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Apr 9 |
| Edson Alvarez | MID | Out | Suspended | Suspended | Nov 10 |
| Vladimir Coufal | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 11 |
| Lucas Paqueta | MID | Out indefinitely | Shoulder Injury | Shoulder Injury | Feb 27 |
| Jean-Clair Todibo | DEF | Out | Suspended | Suspended | Oct 2 |
| Crysencio Summerville | F | Out | Ankle/Foot Injury | Ankle/Foot Injury | Feb 6 |
| Tomas Soucek | MID | Out | Groin Strain | Groin Strain | Mar 8 |
| Mohammed Kudus | MID | Out indefinitely | Knock | Knock | Feb 7 |
| Mario Lemina | MID | Out indefinitely | Knock | Knock | Sep 20 |
| Pablo Sarabia | F | Out | Concussion | Concussion | Sep 5 |
| Goncalo Guedes | MID | Out | Knock | Knock | Apr 21 |
| Hwang Hee-chan | F | Out | Knock | Knock | Apr 8 |
| Nelson Semedo | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Aug 15 |
| Matheus Cunha | F | Out indefinitely | Hamstring | Hamstring | Sep 16 |
| Sasa Kalajdzic | F | Out indefinitely | None | Kalajdzic is injured | Mar 16 |
| Jean-Ricner Bellegarde | MID | Out | Ankle/Foot Injury | Ankle/Foot Injury | Mar 19 |
| Boubacar Traore | MID | Out indefinitely | None | Traore is injured | Aug 30 |
| Yerson Mosquera | DEF | Out indefinitely | None | Mosquera is injured | Sep 27 |
| Enso Gonzalez | F | Out indefinitely | None | Gonzalez is injured | Sep 14 |
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