The Premier League has entered its decisive stage. Liverpool, with a solid lead in the standings, is set to host Southampton, which has managed only nine points through 27 matches and sits at the bottom of the Premier League.
These teams will face off at Anfield at 10 a.m. ET in a match that, on paper, favors the home side. However, nothing is set in stone. Is there room for an upset?
Here is my Liverpool vs. Southampton prediction and EPL odds for today's match.
Liverpool vs. Southampton Prediction, Pick, EPL Odds
Liverpool Odds | ||
---|---|---|
Spread | Total | Moneyline |
-2.5 -113 | 3.5 -140 o / +107 u | -1200 |
Southampton Odds | ||
---|---|---|
Spread | Total | Moneyline |
+2.5 -122 | 3.5 -140 o /+107 u | +1800 |
- Liverpool vs. Southampton moneyline odds: Liverpool -1200; Draw +1000; Southampton +1800
- Liverpool vs. Southampton over/under: 3.5 Goals (Over -140, Under +107)
- Liverpool vs. Southampton pick: Over 3.5 Goals
I am backing over 3.5 goals in the Liverpool vs. Southampton match.

Liverpool Prediction
Liverpool heads into this match against Southampton with one clear goal — to extend their lead in the Premier League and add to their six-game unbeaten streak. Arne Slot’s squad is known for its defensive solidity — which is led by Virgil Van Dijk and goalkeeper Alisson Becker — as well as an efficient attack capable of easily scoring.
Led by Mohamed Salah, the EPL’s top scorer and top assist provider, the Reds will aim to secure all three points at Anfield.
With 46 goals scored and only 26 conceded, Liverpool stands as one of the best teams in Europe, making this match — at least on paper — unlikely to pose much of a challenge.

Southampton Prediction
On the other side of the pitch, we have a team that's seemingly Liverpool’s complete opposite.
In 27 matches, the Saints have conceded 65 goals and scored just nine. That's a -46 goal difference, one of the lowest among all of the teams in Europe’s top five leagues.
Although they recently gave Liverpool a tough time in the Carabao Cup, Southampton is expected to struggle for most of this match. Remember, Ivan Juric’s side hasn’t won a game since February 1 (1-0 vs. Ipswich).

Liverpool vs. Southampton Pick
I see no other result than an easy win for Liverpool at Anfield. The Reds owe their top position to their intense offensive power and ability to score goals in any situation.
Additionally, Liverpool boasts one of the best defenses in Europe, having conceded only 40 goals in 46 matches this season.
On the other side of the pitch, Southampton has struggled significantly, scoring just 19 goals while conceding 65 in 27 Premier League matches. That's why for this match, I'm backing Over 3.5 Goals on DraftKings (-150).
Additionally, if you want a little more to sweat, you can place a SGP featuring Mohamed Salah to Score or Assist, along with the Both Teams Not to Score option on FanDuel.
Liverpool vs. Southampton Pick: Over 3.5 Goals (-140) — DraftKings
Same-Game Parlay
- Over 3.5 Goals (-162)
- Mohamed Salah to Score or Assist (-380)
- Both Teams Not to Score (-110)
SGP Payout +414 — FanDuel