The most bye weeks of the season plus a flurry of injuries make this Sunday's start/sit decisions among the trickiest we'll make in 2021.
To help, I've outlined my final tiers for each position based on the robust round of updates I made to my projections on Saturday afternoon. As always, these won't reflect final actives/inactives, so make sure you consult my real-time rankings before locking in your lineups here. San Francisco will feature heavy rain for the 49ers' showdown against the Colts — before you flood me with questions, I'm factoring the forecast into my projections and will continue to update as the situation is … fluid.
Now let's dive in so you can start setting your lineups without players on the following bye-week teams: Bills, Cowboys, Jaguars, Chargers, Vikings and Steelers.
Fantasy Rankings & Tiers
Fantasy QB Rankings & Tiers
Tier 1
Patrick Mahomes (@ TEN)
Tier 2
Kyler Murray (vs. HOU)
Lamar Jackson (vs. CIN)
Tier 3
Jalen Hurts (@ LV)
Tier 4
Tom Brady (vs. CHI)
Matthew Stafford (vs. DET)