2022 NFL Week 1 Odds
| Matchups | Spreads | Totals |
|---|---|---|
| Bills @ Rams(TNF) | Bills -1 | 52 |
| Saints @ Falcons | Saints -3.5 | 42 |
| Browns @ Panthers | Browns -4 | 43 |
| 49ers @ Bears | 49ers -6.5 | 42.5 |
| Steelers @ Bengals | Bengals -6 | 45 |
| Eagles @ Lions | Eagles -4 | 46.5 |
| Colts @ Texans | Colts -7.5 | 44.5 |
| Patriots @ Dolphins | Dolphins -2.5 | 44.5 |
| Ravens @ Jets | Ravens -4 | 45.5 |
| Jaguars @ Commanders | Commanders -4 | 44.5 |
| Chiefs @ Cardinals | Chiefs -3 | 53 |
| Raiders @ Chargers | Chargers -4 | 52 |
| Packers @ Vikings | Packers -1.5 | 49 |
| Giants @ Titans | Titans -6.5 | 44 |
| Buccaneers @ Cowboys(SNF) | Buccaneers -2.5 | 51 |
| Broncos @ Seahawks(MNF) | Broncos -4 | 41 |
| Odds via DraftKings as of writing | ||
Russell Wilson to Denver was the blockbuster trade of the offseason, and he'll be dealing with his old team in the first week of the new season as the Broncos travel to Seattle for the week's finale on Monday Night Football.
Wilson and the Broncos are 4-point favorites in that contest.
The reigning Super Bowl champions, the Los Angeles Rams, will kick off their season by playing host to the Buffalo Bills on the opening night edition of Thursday Night Football. The visiting Bills are favored to open the season with a win according to the oddsmakers, as they're listed as 1-point favorites.
Los Angeles' Super Bowl victim, the Cincinnati Bengals, will face off with the Pittsburgh Steelers in Paul Brown Stadium as a 6-point favorite.
Tom Brady and the Tampa Bay Buccaneers will open the season with a trip to Dallas for the other primetime game on Sunday Night Football.
If their matchup is anything like the thrilling season-opener from last year, we're in for a serious treat. In that epic, Brady led a game-winning field goal drive to close out a 31-29 victory. The Bucs are favored by 2.5 and the total is a hefty 51.
Elsewhere in the league, Patrick Mahomes and the Kansas City Chiefs will visit the Arizona Cardinals while reigning MVP Aaron Rodgers and the Green Bay Packers will square off against their division rivals, the Minnesota Vikings.
