The NFL Week 13 Sunday slate will be capped off with the San Francisco 49ers (5-6) and Buffalo Bills (9-2) at Highmark Stadium for Sunday Night Football.
Kickoff will be at 8:20 p.m. ET on NBC and Peacock.
You can find my three 49ers vs Bills anytime touchdown picks and predictions below.
49ers vs Bills Anytime Touchdown Picks
- Josh Allen Anytime Touchdown (+130; FanDuel)
- George Kittle Anytime Touchdown (+275; bet365)
- Jauan Jennings Anytime Touchdown (+350; bet365)
Josh Allen
Anytime Touchdown Scorer (+130)
The newly engaged Josh Allen not only has five rushing touchdowns this season, but touchdowns in back-to-back games.
San Francisco’s defense is totally battered with Nick Bosa and Dre Greenlaw listed out. Not only that, you’re starting to see the run defense slipping.
The Niners have allowed five rushing touchdowns over the last two games and rank 21st in defensive DVOA against the run.
If the Bills’ passing game is struggling from the weather, look for Allen to impose his will and seal the deal for a touchdown in a third consecutive game.
George Kittle
Anytime Touchdown Scorer (+275)
George Kittle leads all tight ends in red zone targets and touchdowns, finding the endzone eight times this season in nine games played.
He’s tied with Ja’Marr Chase with 10 targets inside the 10-yard line which is most in the NFL.
The Bills defense is tough, but the Niners should still be able to move the ball with efficiency.
Since it’s going to be a bad weather game, I’d look for the big targets in the end zone. Kittle is the perfect solution here.
Jauan Jennings
Anytime Touchdown Scorer (+350)
Jauan Jennings’ stock has taken off with Brandon Aiyuk being out for the season.
In the four games this season without the star receiver, Jennings has 41 targets and four touchdowns, with seven of them being in the red zone.
He’s the clear-cut WR1 now and has led the Niners in target share against both man and zone coverages.
At these odds, I’m happy to take a swing that either he or Kittle score. If both manage, then all the better.
