49ers vs. Seahawks Odds: Opening Week 12 Spread, Total for Thanksgiving

49ers vs. Seahawks Odds: Opening Week 12 Spread, Total for Thanksgiving article feature image
Credit:

Christopher Mast/Getty Images. Pictured: Brock Purdy #13 of the San Francisco 49ers.

49ers vs. Seahawks Odds

49ers Logo
Thursday, Nov. 23
8:20 p.m. ET
NBC
Seahawks Logo
49ers Odds
SpreadTotalMoneyline
-7
-110
43
-110o / -110u
-310
Seahawks Odds
SpreadTotalMoneyline
+7
-110
43
-110o / -110u
+250
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

Header First Logo

49ers

The 49ers are back to their dominant ways after dropping three-straight games before their bye week. They beat up on the Jaguars 34-3 two weeks ago, and then won 27-14 Sunday against the Buccaneers. They failed to cover, though, and are 1-4 against the spread over their last five games.

It’s been nine years since the Niners last played on Thanksgiving, falling 19-3 against these very same Seahawks. The 49ers have a 30-20 edge in the all-time series against their archrivals. They’ve won three-straight against them including last year’s playoff win, doing so by an average of 15.3 points.

Bet 49ers vs. Seahawks at bet365 with our bet365 bonus code.

Header First Logo

Seahawks

Seattle blew a 16-7 lead to their division foe Rams, but they may have lost even more as Geno Smith (elbow) and Kenneth Williams (oblique) were injured. They now face a quick turnaround against another NFC West foe in the 49ers.

The Seahawks are 2-2 all-time on Thanksgiving, and this marks their first game since 2014 in the aforementioned win over the 49ers. They also return home where they’re 4-1 straight up but 2-3 against the spread. Meanwhile, the over is 3-2 at Lumen Field and has hit in two straight.

Header First Logo

49ers vs. Seahawks

Early Picks & Predictions

Download the Action App and follow our experts to get instant notifications for when they make a 49ers vs. Seahawks pick.

This site contains commercial content. We may be compensated for the links provided on this page. The content on this page is for informational purposes only. Action Network makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event.