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49ers vs Vikings Odds, Spread, Total for NFL Week 2

49ers vs Vikings Odds, Spread, Total for NFL Week 2 article feature image
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SANTA CLARA, CALIFORNIA – AUGUST 18: Brock Purdy #13 of the San Francisco 49ers scrambles with the ball against the New Orleans Saints during the first half of a preseason game at Levi’s Stadium on August 18, 2024 in Santa Clara, California. (Photo by Thearon W. Henderson/Getty Images)

49ers vs Vikings Odds for NFL Week 2

49ers Logo
Sunday, Sep 15
1 p.m. ET
CBS
Vikings Logo
49ers Odds
SpreadTotalMoneyline
-5
-110
45
-110o / -110u
-230
Vikings Odds
SpreadTotalMoneyline
+5
-110
45
-110o / -110u
+190
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

The 49ers (1-0) face the Vikings (1-0) in Week 2 of the NFL season with kickoff set for 1 p.m. ET at U.S. Bank Stadium in Minneapolis, Minnesota. Here's an early look at the 49ers vs. Vikings odds, spread and total for this Sunday afternoon matchup.

The 49ers are favored by 5 points over the Vikings in the latest NFL odds for Week 2, with the over/under set at 45.

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San Francisco 49ers

There seems to be a lot of concern that Christian McCaffrey doesn't suit up for Week 2, after unexpectedly missing the team's season opener vs the Jets with a calf and Achilles injury.

Jordan Mason stepped up in a massive way though, setting career highs in carries (28) and rushing yards (147). If McCaffrey can't go again, the Niners have no problem sending out Mason once again.

Minnesota Vikings

The Vikings return home after obliterating the Giants, 28-6. The big story was the play of Sam Darnold, who looked fantastic in his first game for Minnesota. He was 19-of-24 for 208 yards, two touchdowns and one interception in his return to the Meadowlands.

49ers vs Vikings Picks

About the Author
Ricky Henne writes for the Action Network's news team, covering all sports, events and breaking news. He also contributes to Action's NFL coverage. Ricky joined Action in 2022 with more than 20 years of experience covering professional sports. He wrote for the Los Angeles Chargers, New York Knicks and New York Rangers before entering the sports betting industry.

Follow Ricky Henne @rickyhenne on Twitter/X.

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