The Arizona Cardinals (7-8) and Los Angeles Rams (9-6) wrap up the Saturday NFL tripleheader. Kickoff for this NFC West clash is set for 8:10 p.m. ET from SoFi Stadium in Inglewood, Calif. The game will be broadcast live on NFL Network.
Cardinals vs Rams odds have the Rams as -340 moneyline favorites and Cardinals as +270 underdogs. The Rams are 6.5-point favorites on the spread (-6.5; +100 at DraftKings) and the game total has an over/under of 48 (-112o/ -108u).
Let's get into my Cardinals vs Rams predictions and picks for Saturday night, plus the latest betting trends for key markets, inactives (Arizona RB James Conner is active), weather forecast and more.
Cardinals vs Rams Predictions
Against the Spread
Despite the injuries on the Arizona side, I see these teams as more evenly matched than the spread indicates.
- 65% of bets and 72% of the money are on the Rams to cover the spread
I'm going against the public and taking Cardinals +6.5 on Saturday night.
Moneyline
While I like Arizona against the spread, I won't be betting the Cardinals on the moneyline.
- 93% of bets and 96% of the money are on the Rams moneyline
Over/Under
I also do not see value on the total in this matchup.
- 66% of bets and 61% of the money are on the over
My Pick: Cardinals +6.5 (+100; DraftKings)
Cardinals vs Rams Odds, Spread, Over/Under, Best Bets
| Cardinals Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
+6.5 +100 | 48 -112o / -108u | +270 |
| Rams Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
-6.5 -120 | 48 -112o / -108u | -340 |
- Cardinals vs Rams spread: Cardinals +6.5 (+100), Rams -6.5 (-120)
- Cardinals vs Rams over/under: 48 (-112o / -108u)
- Cardinals vs Rams moneyline: Cardinals +270, Rams -340
- Cardinals vs Rams best bet: Cardinals +6.5 (+100)
MyCardinals vs. Rams best bet is on the Cardinals to cover the spread. For all of your NFL bets, be sure to find the best lines by using our live NFL odds page.
Cardinals vs Rams Week 17 Preview, Prediction
We have one last chance (probably) to win money on the NFC West.
Even with the injuries to the Cardinals, I don’t think these teams are very far apart. Arizona might be without both of its offensive tackles and RB James Conner, but I don’t see the difference between these teams being indicative of this spread.
In terms of DVOA rankings, the Rams are ninth on offense to the Cardinals’ 11th, but Arizona has the edge on defense by four spots at 16th. The Rams’ special teams is also worse.
This line reeks of recency bias and motivation. The Rams have surged to the top of the NFC West after a 1-4 start, while the Cardinals have been eliminated from playoff contention with four losses in their last five games. There’s no denying that these teams are trending in opposite directions.
This is the Cardinals’ Super Bowl now, though. Next week, they finish the season against the 49ers in a meaningless game for both sides. This is their last chance to make an impact on the division race.
In Week 16 and later, teams with a win percentage between 40-60% (Rams are 60%) facing teams with a win percentage between 8-25% lower are 31-75-5 against the spread. We get between four and seven such matchups every season, and that trend has never finished more than one game below .500 in Bet Labs’ history.
NFC West road underdogs under seven points also cover at a 70% clip, according to Bet Labs, and Kyler Murray is 31-16-2 against the spread as an underdog. Matthew Stafford only covers at a 41% clip when he’s laying three or more points.
My Pick: Cardinals +6.5 (+100; DraftKings)
Cardinals vs Rams Betting Trends
Cardinals Trends
- Cardinals are 5-0 in their last 5 games against the spread
- Cardinals are 4-3 in their road games against the spread
- The totals have gone OVER in 1 of Cardinals' last 5 games
Rams Trends
- Rams are 4-1 in their last 5 games against the spread
- The totals have gone OVER in 2 of Rams' last 5 games
- The totals have gone OVER in 4 of Rams' 7 last games at home
Cardinals vs Rams Inactives
Cardinals Inactives
- S Jammie Robinson
- S Joey Blount
- RB Trey Benson
- LB Milo Eifler
- LB Benton Whitley
- TE Travis Vokolek
- WR Xavier Weaver
Rams Inactives
- OL Rob Havenstein
- QB Stetson Bennett
- WR Tyler Johnson
- RB Code Schrader
- OL Dylan McMahon
