ArizonaCardinals head coach Kliff Kingsbury is among notable personnel slated to miss Sunday's Week 6 contest at the Cleveland Browns after testing positive for COVID-19.
Quarterbacks coach Cam Turner and defensive tackle Zach Allen won't travel, either.
Defensive coordinator Vance Joseph and assistant head coach/special teams coordinator Jeff Rodgers are expected to take Kingsbury's duties.
Arizona is a three-point road underdog at DraftKings.
Kingsbury, in his third season, is piloting the league's lone undefeated team at 5-0.
The Cardinals have been the class of a cutthroat NFC West, ranking sixth in yards per play and eighth in DVOA offense.
The franchise is on pace to finish above .500 for the first time in the Kingsbury era, led by quarterback Kyler Murray.
The dual-threat QB is a legitimate MVP candidate in his third year, accounting for 1,512 passing yards, another 110 on the ground and 13 total touchdowns.
Arizona's been money for bettors seemingly all year, cashing all but one spread. Kingsbury had been dynamite as a road underdog, going 10-3-2 against the spread the last 15.
The Browns, meanwhile, are 5-1 ATS after failing to cover, which applies after last week's seven-point loss to the Chargers.
The total for Sunday's matchup opened at a whopping 54 points, but it has since been bet down to 49.
The expected weather for Cleveland includes potential winds, which could suppress two quarterbacks who like to chuck it: Murray and Mayfield rank third and sixth in yards per attempt this season.
