Cardinals vs 49ers Odds, Spread, Total | NFL Week 5

Cardinals vs 49ers Odds, Spread, Total | NFL Week 5 article feature image
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Getty Images. Pictured: Kyler Murray, Brock Purdy.

Cardinals vs 49ers Odds for NFL Week 5

Cardinals Logo
Sunday, Oct 6
4:05 p.m. ET
FOX
49ers Logo
Cardinals Odds
SpreadTotalMoneyline
+7.5
-110
49.5
-110o / -110u
+275
49ers Odds
SpreadTotalMoneyline
-7.5
-110
49.5
-110o / -110u
-350
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

The Cardinals (1-3) face the 49ers (2-2) in Week 5 of the NFL season with kickoff set for 4:05  p.m. ET at Levi Stadium in Santa Clara. Here's an early look at the Cardinals vs. 49ers odds, spread and total for this Sunday afternoon matchup.

The 49ers are 7.5-point favorites over the Cardinals in the latest NFL odds for Week 5, with the over/under set at 49.5.

Cardinals

Arizona’s defense was drubbed yet again in a 42-14 Week 4 loss. They’ve now given up the fourth-most points in the league (26.5).

Meanwhile, an offense that was electric the first two weeks of the season struggled yet again. They’ve scored 27 points over their last two weeks after scoring 69 points in their first two. The Cardinals are 1-3 SU and 2-2 ATS.

49ers

The 49ers got two of their biggest playmakers back and no-so-coincidentally got off the schneid.

George Kittle caught four passes for 45 yards and a TD while Deebo Samuel had five touches for 72 yards as the 49ers downed the Patriots, 30-13, as a 10.5-point favorite. The 49ers are 2-2 SU and ATS.

Cardinals vs 49ers Picks

About the Author
Ricky Henne writes for the Action Network's news team, covering all sports, events and breaking news. He also contributes to Action's NFL coverage. Ricky joined Action in 2022 with more than 20 years of experience covering professional sports. He wrote for the Los Angeles Chargers, New York Knicks and New York Rangers before entering the sports betting industry.

Follow Ricky Henne @rickyhenne on Twitter/X.

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