Chargers vs Cardinals Odds, Spread, Total | NFL Monday Night Football

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Photo by Patrick McDermott/Getty Images Pictured: Kyler Murray of the Arizona Cardinals

Chargers vs Cardinals Odds for NFL Week 7

Chargers Logo
Monday, Oct 21
9:00 p.m. ET
ESPN+
Cardinals Logo
Chargers Odds
SpreadTotalMoneyline
-2.5
-110
43.5
-110o / -110u
-140
Cardinals Odds
SpreadTotalMoneyline
+2.5
-110
43.5
-110o / -110u
+120
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

The Chargers (3-2) face the Cardinals (2-4) in Week 7 of the NFL season, with kickoff set for 9:00 p.m. ET at State Farm Stadium in Glendale. Here's an early look at the Chargers vs. Cardinals odds, spread and total for this Monday night matchup.

The Chargers are 2.5-point favorites over the Cardinals in the latest NFL odds for Week 7, with the over/under set at 43.5.

Chargers

A Chargers team that relies heavily on the run let Justin Herbert air it out last week far more than he had all year. He had his most completions (21), yards (237), and attempts (34) as his injured ankle looked much improved.

The Bolts’ defense continues to be a force to be reckoned with as they lead the league in points against. Los Angeles is 3-2 SU and 3-1-1 ATS.

Cardinals

Arizona’s up-and-down season continued Sunday in a 34-13 loss to the Packers. The Cardinals' offense has run hot and cold, and they might be without star wideout Marvin Harrison, as the rookie suffered a concussion early in Green Bay.

Arizona’s defense has struggled mightily, as they’re giving up the fifth-most points per game in the league (27.2). The Cardinals are 2-4 SU and 3-3 ATS.

Chargers vs Cardinals Picks

About the Author
Ricky Henne writes for the Action Network's news team, covering all sports, events and breaking news. He also contributes to Action's NFL coverage. Ricky joined Action in 2022 with more than 20 years of experience covering professional sports. He wrote for the Los Angeles Chargers, New York Knicks and New York Rangers before entering the sports betting industry.

Follow Ricky Henne @rickyhenne on Twitter/X.

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