Chiefs vs Chargers Picks, Odds, Predictions for NFL Week 4

Chiefs vs Chargers Picks, Odds, Predictions for NFL Week 4 article feature image
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Patrick Mahomes #15 of the Kansas City Chiefs and Travis Kelce #87 of the Kansas City Chiefs. (Photo by Kevork Djansezian/Getty Images)

Sharp NFL bettors and big money are fading one offense in particular for Chiefs vs. Chargers this Sunday, producing two picks in PRO.

The Chiefs face off against the Chargers at SoFi Stadium, marking the first division game of the year for Kansas City. Kickoff is scheduled for 4:25 p.m. ET.

The Chiefs, led by star quarterback Patrick Mahomes and tight end Travis Kelce, enter the game with a perfect 3-0 record. Meanwhile, the Chargers, helmed by first-year head coach Jim Harbaugh, stand at 2-1.

The Chiefs are favorites, with the spread favoring them at -7.5 and the over/under set at 40 points. As the anticipation builds for this AFC West showdown, bettors are keen to dissect the odds and find the best betting angles.

Chiefs vs. Chargers Odds, Picks, Predictions

Chiefs Logo
Sunday, Sep 29
4:25 p.m. ET
CBS
Chargers Logo
Chiefs Odds
SpreadTotalMoneyline
-7.5
-110
40
-110o / -110u
-365
Chargers Odds
SpreadTotalMoneyline
+7.5
-110
40
-110o / -110u
+285
Odds via Caesars. Get up-to-the-minute NFL odds here.
Caesars Logo
  • Chiefs vs. Chargers spread: Chiefs -7.5
  • Chiefs vs. Chargers over/under: 40 (o-110, u-110)
  • Chiefs vs. Chargers moneyline: Chiefs: -365, Chargers +285

Spread

Mahomes and the Chiefs are -7.5 on the spread vs. the Chargers this Sunday

Over/Under

The over/under is set at 40 points, with each side marked at -110.

Moneyline

The Chiefs are -365 to win outright, the Chargers are listed at +285.

Player Prop

Scanning PRO Props, one prediction holding a minor edge is Chargers WR Ladd McConkey to score a touchdown at any point of the game. His odds to score an anytime touchdown are +380 at FanDuel, but we think the fair price should be more like +334.

Chiefs vs. Chargers Prediction

Both the spread and over/under feature PRO insights converging on multiple predictions.

Point Spread

Our analysis indicates that 100% of our top NFL experts are locking in