DeAndre Hopkins is expected to miss the rest of the regular season after spraining his knee against the Los Angeles Rams on Monday in a 30-23 loss.
The Cardinals are "hopeful" that their star wideout will return for the postseason, ESPN reported on Wednesday.
The news hasn't moved the Cardinals' Super Bowl odds at any of the major American sportsbooks.
But, it's altered their odds to win the NFC Championship and the NFC West at some books.
At DraftKings, Arizona's odds to make the Super Bowl went from +425 to +500. They still remain the third-best favorites behind the Tampa Bay Buccaneers (+225) and Green Bay Packers (+350), though.
The Cowboys (+600) and Rams (+600) round out the top five in that category.
The Cardinals' odds to win the NFC remained unchanged at FanDuel (+460), PointsBet (+450) and BetMGM (+450).
Meanwhile, their odds to win the NFC West fell from -750 to -600 at FanDuel. In a corresponding move, the Rams saw their divisional odds shorten from +550 to +490 and the San Francisco 49ers had their odds altered from +8500 to +5000.
The Cardinals' odds to win the NFC West did not change at DraftKings (-700), PointsBet (-750) and BetMGM (-833).
Arizona's loss to the Rams on Monday Night Football precipitously diminished their chances of nabbing the No. 1 seed in the NFC. It looks very likely that their road to the Super Bowl will require trips to either Green Bay or Tampa — potentially, even both.
The Cardinals had pole position for the No. 1 seed before their loss on Monday.
While they're still in a three-way tie with the Packers and Bucs atop the NFC — all at 10-3 — the Cardinals' strength of schedule is substantially more difficult. After Kyler Murray and company play the Lions this week, they host the Colts, play a road game at the Cowboys and host a feisty Seahawks team.
Meanwhile, the Bucs play an easier schedule: at home against the Saints, two games against the Panthers and away at the hapless Jets.
The Packers play at Baltimore, at Lambeau against the Browns and Vikings, then in Detroit against the Lions.
