NFL Week 17 wraps up on Monday Night Football with the Lions (13-2) and 49ers (6-9) playing tonight at Levi's Stadium in Santa Clara, Calif., at 8:15 p.m. ET on ABC and ESPN.
The Lions are 3.5-point favorites on the spread over the 49ers with the game total set at 50 at BetMGM, where the Lions are -190 favorites on the moneyline, while the 49ers are +155.
Our experts have Lions vs. 49ers predictions, including NFL player props.
Lions vs. 49ers Odds for Monday Night Football
- Spread: Lions -3.5
- Over/Under: 50.5 (-108 / -112)
- Moneyline: Lions -218, 49ers +180
Odds via DraftKings. Get the latest NFL odds here.
Lions vs. 49ers Parlay
You can create a parlay using our picks at DraftKings for a +650 Monday Night Football SGP.
- Lions -3.5
- Over 50.5
- George Kittle Anytime TD Scorer
Lions vs. 49ers Parlay Odds: +650 at DraftKings
Lions vs. 49ers Pick Against the Spread
By Billy Ward
The Vikings and Lions are set up for a winner-take-all Week 18 matchup for the No. 1 seed and NFC North crown. By contrast, the 49ers have already been eliminated from the playoffs, and haven't beaten anyone besides the Bears in the last six weeks.
That's a pretty wide gap in motivation. If anything, the 49ers would be better served by losing their remaining games to improve their draft standing.
Plus, the Lions match up extremely well here. San Francisco has a tough pass defense (fifth by DVOA) but struggles against the run (24th) — and the Lions love to play through their run game.
On the other side of the ball, Detroit's defense is banged up — especially its defensive line — but the 49ers are missing at least two, — probably three — of their top offensive tackles. That will make it hard for the 49ers to attack downfield if they fall behind.
Put that together, and we have a perfect storm for the Lions to turn this into a blowout. They should be able to run the ball at will while San Francisco struggles to keep pace behind a piecemeal offensive line.
If and when the Lions get a lead, this one should be over.
Pick: Lions -3.5 (-102)
Lions vs. 49ers Over/Under Prediction
By John LanFranca
With the state of the Lions defense in shambles due to injuries, there is no reason to expect them to stop playing in shootouts any time soon.
Over the past month, Detroit has allowed 8.7 yards per pass attempt — the most in the league. Each of its last three games have gone over the total with 51 total points or more scored.
The 49ers should come out with a pass-heavy game plan once again. Last week, Kyle Shanahan called the highest rate of passes for any Niners game this season.
