49ers vs. Titans Odds
| 49ers Odds | -3 |
| Titans Odds | +3 |
| Over/Under | 44.5 |
| Time | 8:20 p.m. ET |
| TV | NFL Network |
| Odds via DraftKings. Get up-to-the-minute NFL odds here. | |
The Titans and 49ers kick off a raucous Week 16, which features plenty of games with playoff implications.
Both Tennessee (No. 3 seed in the AFC) and San Francisco (No. 6 in NFC) would be in the postseason if it started today. However, a win for either team makes the road ahead that much less challenging.
Other than Titans running back Derrick Henry, most notable skill players should be available tonight.
As bettors dive into the player prop market for 49ers vs. Titans, they're keen on a couple San Francisco pass-catchers.
49ers-Titans Most Popular NFL Player Props
- Deebo Samuel to score first touchdown (+600)
- Deebo Samuel to score anytime touchdown (+115)
- George Kittle to score and 49ers to win (+170)
Bettors like Samuel to find the end zone, preferably the opening touchdown of the game. That would cash both the first and anytime score in one play.
The third-year receiver's +600 price tag to hit paydirt first is the shortest among Thursday's field. He's ahead of Jeff Wilson Jr. (+750) and Kittle (+800) as the only three players at 10-1 or shorter.
Samuel may not be a consistent threat in the passing game — he's been held to one catch in three of his last four games — but has been used as a Swiss-army knife in Kyle Shanahan's offense, posting more rushing touchdowns (seven) than receiving (five).
Overall, Samuel's 12 total touchdowns this year rank second among wide receivers.
Bettors, meanwhile, also hit Kittle to score a touchdown plus a 49ers win, which would pay out $170 on a $100 wager.
Kittle's main battle in 2021 has been staying healthy; otherwise, he's been excellent. The star tight end ranks inside the top five at his position in snap share, target share, air yards share, target rate, receptions, yards and fantasy points per contest this season, among other categories.
