The Dallas Cowboys and Tampa Bay Buccaneers will open the NFL season on Thursday, Sept. 9 at 8:20 ET.
The defending Super Bowl champions will start their campaign against America's Team, which finished 6-10 last season and missed the playoffs for the second straight season.
The Buccaneers beat the Kansas City Chiefs 31-9 in Super Bowl LV for Tom Brady's seventh Super Bowl ring.
How To Watch the NFL's 2021 Season Kickoff
The game will air on NBC, with the pregame show beginning at 7 p.m. ET.
How To Stream Cowboys vs. Buccaneers
Those that wish to stream the season opener can do so on Peacock or the NBC Sports app.
Cowboys vs. Buccaneers Odds, Futures
The Bucs are currently 9-point favorites over the Cowboys with a -450 moneyline at BetMGM. Dallas is +350 underdogs against the defending champions at the sportsbook as of Thursday.
The total for the game is 52.5 (-110).
The line has moved since opening at Bucs -7.5 and at a -375 moneyline.
The Bucs are currently BetMGM's largest liability to win the Super Bowl this season with about 20% of the total money and about 13% of the total tickets. Their odds to win it all opened as tied for third-best at +1200 before they moved all the way down to +650 in July.
The line then settled to +700 in August, where it stands now.
Tampa also has the shortest odds to win the NFC (+300) and finish as the No. 1 seed in the conference (+160).
The Cowboys are tied for 11th in the NFL for the shortest Super Bowl odds at +3000, along with the Los Angeles Chargers and New England Patriots.
Dallas has the best odds to win the NFC East at +130, ahead of the Washington Football Team at +220, the New York Giants at +450 and the Philadelphia Eagles at +500.
