The Jacksonville Jaguars (4-12) and Indianapolis Colts (7-9) will face off in NFL Week 18 at 1 p.m. EST from Lucas Oil Stadium in Indianapolis. The game will be broadcast live on FOX and can be streamed on platforms like YouTube TV.
The Colts are favored by 3.5 points over the Jaguars (Colts -3.5) after the spread was -5 late last week. The game total is over/under 44.5 (-110o / -110u), while the Colts are -180 favorites to win outright and Jaguars are +150.
Let's get into my Colts vs Jaguars predictions and NFL picks.
Jaguars vs. Colts Prediction
Spread
Mac Jones vs. Joe Flacco. I am salivating over this Week 18 AFC South matchup.
I believe the Colts are getting too much respect in this spot and I am backing the Jaguars at +5 as a result.
Moneyline
I wouldn't blame you for sprinkling on the Jags moneyline, but my bet is on the spread.
Over/Under
I have no bet on the game total.
My Pick: Jaguars +3.5
Jaguars vs. Colts Odds
| Jaguars Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+3.5 -110 | 44.5 -110o / -110u | +150 |
| Colts Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-3.5 -110 | 44.5 -110o / -110u | -180 |
- Jaguars vs. Colts spread: Colts -3.5 (-110), Jaguars +3.5 (-110)
- Jaguars vs. Colts over/under: 44.5 (-110o / -110u)
- Jaguars vs. Colts moneyline: Colts -180, Jaguars +150
For all of your NFL bets, be sure to find the best lines by using our live NFL odds page.
Jaguars vs. Colts Betting Preview
- 56% of bets and 70% of money on the spread are on the Colts to cover.
- 77% of bets and 79% of money on the total are on the OVER.
- 90% of bets and 84% of money on the moneyline are on the Colts to win outright.
Jacksonville Jaguars vs. Indianapolis Colts Picks
What better way to end the NFL season than by backing Mac Jones as a road underdog against Joe Flacco?
Sportsbooks must think it’s Week 7 with this line at Jaguars +5/+4.5.
The Colts quit last week, somehow allowing 45 points to the Giants in a catastrophic loss. It’s been nothing but fingerpointing and drama in Indy this entire week – the vibes could not be worse.
Yet somehow the books think the Colts are 4.5-to-5 points better than the Jaguars.
Insane. This line should be Colts -3.
The Colts have never matched up well against the Jaguars, even during the Peyton Manning and Andrew Luck years it was a thing.
Indianapolis is 15-26-2 against the spread (ATS) vs. Jacksonville in the last 20 years. The Jags are by far the least profitable opponent ATS for the Colts – and it hasn’t been any better lately.
The Colts are 2-7 ATS vs. the Jaguars since 2020; they are 3-15-1 ATS vs. the Jaguars since 2015.
The Jaguars also aren’t showing any signs of quitting, winning two of their last four games. I think Jones will be able to move the ball against a terrible Colts defense.
The Jags will keep this game close and could even win outright. Take the points in what might be our last chance to fade Flacco as a favorite.
My Pick: Jaguars +3.5
