The Kansas City Chiefs (9-1) and Carolina Panthers (3-7) face off in NFL Week 12. Kickoff is set for in 1 p.m. ET from Bank of America Stadium in Charlotte. The game will be broadcast live on CBS and can be streamed on Paramount+.
The Chiefs are favored by 11 points over the Panthers with the game total set at 43. The Chiefs are -600 favorites to win outright, while the Panthers are +450 to pull off the upset.
The Chiefs lost 30-21 to the Bills last week for their first loss of the season. Patrick Mahomes threw two interceptions and now has 11 on the season, which is three shy of his career high with seven games left. The Panthers are coming off their bye week but have won their last two games. Bryce Young is back under center and has avoided back-breaking turnovers in those wins.
Let's get into my Chiefs vs. Panthers predictions and NFL picks.
Chiefs vs. Panthers Odds, Pick, Prediction
| Chiefs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-11 -110 | 43 -110o / -110u | -600 |
| Panthers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+11 -110 | 43 -110o / -110u | +450 |
- Chiefs vs. Panthers spread: Chiefs -11
- Chiefs vs. Panthers over/under: 43 (-110o / -110u)
- Chiefs vs. Panthers moneyline: Chiefs -600, Panthers +450
- Chiefs vs. Panthers best bet: Panthers +11 (-110)
MyChiefs vs. Panthers pick is on the underdog. For all of your NFL bets, be sure to find the best lines by using our live NFL odds page.
Spread
Pinch your nose and take the points.
Bryce Young only has one interception in his last two games and is leading a competent Panthers offense into a matchup against the Chiefs, who have struggled as big road favorites in recent years.
Kansas City is 0-3-1 against the spread when laying double-digit points this season.
Moneyline
I'm not going to bet on the Panthers to win this game outright and will focus my bet on the spread.
Over/Under
I project this total at 42.5 points, so I'm very close to being in line with the market and I don't have a pick on it.
My Pick: Panthers +11 (-110)
Chiefs vs. Panthers NFL Week 12 Preview
Bryce Young is one of the worst quarterbacks we’ve seen in the past two decades — if not the worst. Just as was the case with Anthony Richardson, Young got benched, took a break, came back and has won by not turning the ball over (as much) and avoiding huge mistakes.
We’ve also seen more in-game leadership from Young. It was like I saw a different guy than the one who started his career so poorly.
The Panthers are getting healthier on both sides of the ball, and the offensive line is protecting Young better than ever.
Now Carolina faces a Chiefs team that just had a very impressive winning streak broken, dating all the way back to last season. You could say this is a bounce-back spot for Kansas City, but I see this more as a game in which it could be a bit deflated after putting so much into last week’s loss to the Bills.
The Panthers are coming off their bye week, which I think will be beneficial for Young. He improved after getting benched, and I think an extra week to prepare for the defending champs will have done him and head coach Dave Canales very well.
Young has started the Panthers’ last three games. He mostly struggled against Denver with two second-half interceptions, but he ended that game with a touchdown drive.
Since then, Young has only committed one turnover in the Panthers’ last two games, both of which they won. His stats were unspectacular, but avoiding turnovers is hugely important in the NFL.
The Panthers offense is showing signs of promise outside of Young, too.
Chuba Hubbard is having a career season, and rookie RB Jonathan Brooks is entering the fold. Jonathan Mingo was traded, but WR Xavier Legette has stepped up, as has TE Ja'Tavion Sanders. Also, veteran receiver Adam Thielen is nearing a return.
A key trend for this game is that Patrick Mahomes generally struggles as a big favorite. Mahomes is 19-34 against the spread (ATS) since November 2021 when laying more than a field goal. This season, Mahomes has been a double-digit-point favorite four times — he’s 0-3-1.
By the way, seven of Mahomes’ 10 interceptions this season have come in a clean pocket. The Panthers don’t put a lot of pressure on the quarterback, but that might not be much of an issue here.
I rarely bet against the Chiefs, but I’m taking 11 points here on a home 'dog with a low total.
My Pick: Panthers +11 (-110)
Panthers vs Chiefs Betting Trends
NFL Weather
