Monday Night Football Spread Pick for Jaguars vs Bills

Monday Night Football Spread Pick for Jaguars vs Bills article feature image
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Photo by Megan Briggs/Getty Images. Pictured: Head coach Doug Pederson of the Jacksonville Jaguars looks on

Jacksonville Jaguars vs. Buffalo Bills is the first game on tonight's NFL slate for bettors looking to make a Monday Night Football pick.

The Bills are 5.5-point spread favorites against the Jaguars based on the latest NFL odds, with the over/under set at 45.5.

Jaguars vs. Bills is also a match for an Action PRO betting system with a 102-69-3 (60%) against-the-spread (ATS) win rate dating back to the 2005 NFL season.

So what is the smartest way for bettors to approach Jaguars vs. Bills tonight?

To answer that question, let's look at the Monday Night Football pick that fits nicely into a historically profitable spread betting system.

The 60% Against-the-Spread Monday Night Football Pick

*Odds as of Monday morning

Seventy-three percent of tickets have come in on Buffalo thus far according to our NFL public betting data.

While not as lopsided, 58% of the money is backing Josh Allen and Company as well.