The New England Patriots (3-10) and Arizona Cardinals (6-7) will face off in NFL Week 15 at 4:25 p.m. ET from State Farm Stadium in Glendale. The game will be broadcast live on CBS.
Let's get into my Cardinals vs Patriots predictions and NFL picks.
The Cardinals are favored by 6 points with the game total set at 46 points scored. The Cardinals are -260 favorites to win outright, while the Patriots are +210 to pull off the upset.
The Patriots lost 25-24 to the Colts last week. Drake Maye threw for 238 yards, but New England thrived with 200 rushing yards. The Cardinals lost 30-18 to the Seahawks last week and have lost 3 straight. Kyler Murray threw for 259 yards and 2 touchdowns but also 2 interceptions.
Patriots vs. Cardinals Prediction
Spread
While I don't have a pick on the full-game spread, I like the Cardinals to cover the first-half spread against the Patriots.
Moneyline
I don't see any value on the moneyline in this one.
Over/Under
I don't have a pick on the total in this game either.
My Pick: Cardinals 1H -3.5
Patriots vs. Cardinals Odds, Spread, Over/Under
| Patriots Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+6 -110 | 46 -110o / -110u | +210 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-6 -110 | 46 -110o / -110u | -260 |
- Patriots vs. Cardinals spread: Cardinals -6
- Patriots vs. Cardinals over/under: 46 points scored
- Patriots vs. Cardinals moneyline: Cardinals -260, Patriots +210
- Patriots vs. Cardinals best bet: Cardinals 1H -3.5
MyPatriots vs. Cardinals best bet is on Cardinals 1H -3.5. For all of your NFL bets, be sure to find the best lines by using our live NFL odds page.
New England Patriots vs. Arizona Cardinals Preview
This would usually be a spot that I’d be looking to fade the Patriots. They’re coming off a tough loss (but they covered!) and have to travel across the country to face a team playing for its playoff life.
Also, the Patriots defense is the worst in the NFL in Weighted DVOA, which takes into account recent performances more than the entirety of the season. It’s not like defensive DVOA is kinder to New England, which is 31st in that category.
The Cardinals are 14th in Weighted DVOA on defense and 10th on offense. They have lost three straight, but the performances haven’t been that bad.
Arizona ran into a surging Seahawks team — that just got its defense healthy recently — twice in the last three games, with a trip to face the Vikings sandwiched between those losses.
While obviously being two games behind the Seahawks and losing the tiebreaker has all but doomed the Cardinals’ playoff hopes, I don’t anticipate Arizona will just lay down and accept that its season is over.
So, how do we do that?
I’m hesitant to recommend a bet on the Cardinals against the spread (ATS) since Kyler Murray notoriously struggles later in the season. He’s 26-14 ATS in September or October in his career, but 16-21-2 after Nov. 1.
This season, Drake Maye is 2-6 against the first-half spread, which is the third-worst mark in the NFL ahead of only Trevor Lawrence and Caleb Williams. Like Williams, Maye has done well in the second half at 5-1 against the second-half spread in his last six starts.
I’d play the Cardinals against the first-half spread at -4 or lower, but there are still some 3.5s on the board — use our live NFL odds page to find those. If you wanted to parlay that with Patriots 2H +4, I wouldn’t blame you.
My Pick: Cardinals 1H -3.5
Cardinals vs Patriots Betting Trends
NFL Weather
