Our betting experts have Jets vs. 49ers picks for the first Monday Night Football game of the 2024 NFL season, which kicks off from Levi Stadium at 8:15 p.m. ET. 49ers vs. Jets is live on ABC, ESPN for TV channels and streaming on ESPN+, YouTube TV and other streaming platforms.
The San Francisco 49ers are consensus 3.5-point favorites (-3.5) over the New York Jets following the news Christian McCaffrey is out. The Jets vs. 49ers spread has come down from 49ers -4 to 49ers -3.5 following McCaffrey being ruled inactive. The Jets vs. 49ers over/under is now 43 at most places, after having been as high as 43.5 earlier in the day and dropping as low as 42 in the moments after the CMC news. There is a 43.5 back in the market an hour before kick, as well.
We have NFL predictions on the spread, total and a player prop. Let's get to our expert 49ers vs. Jets best bets in our NFL Week 1 Monday Night Football picks and predictions. For the latest lines, make sure to check out our live NFL odds page.
Jets vs. 49ers Picks
| Game | Time (ET) | Pick |
|---|---|---|
  | 8:15 p.m. | |
| 8:15 p.m. | |
| 8:15 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our NFL Odds page, which automatically surfaces the best lines for every game. | ||
Week 1 Monday Night Football Odds
| Jets Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+3.5 -120 | 43 -110o / -110u | +152 |
| 49ers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-3.5 +100 | 43 -110o / -110u | -180 |
- Jets vs 49ers point spread: 49ers -3.5 | Jets +3.5
- Jets vs 49ers over/under: 43 total points
- Jets vs 49ers lines: 49ers -180 | Jets +152
Aaron Rodgers is back and has a great offense on paper with Breece Hall in the backfield and Garrett Wilson leading the receiving corps. New York will face firepower on the other side in its own right with Deebo Samuel, Brandon Aiyuk and George Kittle ready to go for the Niners, even if CMC is out.
Week 1 Monday Night Football Pick Against the Spread
I'm all-in on the Jets, and this is a great spot for New York on Monday night.
I rate the healthy Jets as the best roster in the NFL, just ahead of the Chiefs and 49ers, and if that's the case, we should be betting the Jets aggressively early when they are the healthiest. The 49ers, meanwhile, sort of stumble into this game. Trent Williams and Brandon Aiyuk are finally back but we'll see how much either plays, and Christian McCaffrey was out hurt all preseason too.
We haven't seen Aaron Rodgers this preseason, but you already know I'm in on Rodgers, with his +2500 MVP ticket my top awards play of the preseason. Rodgers has always loved playing the 49ers, the team that passed on drafting him No. 1 overall. He's 6-3 against the Niners with 20 passing TDs and just two interceptions in the regular season.
Road underdogs that missed the playoffs are 57-31-2 ATS (65%) in Week 1 since 2011, so the Jets may be a bit undervalued here. Rodgers is 15-9 ATS (63%) lifetime as an underdog, including 11-13 SU as a dog of over a field goal.
The 49ers have started slowly under Kyle Shanahan. His teams are about rhythm and rounding into peak form, and he's just 2-5 ATS in Week 1. Even worse, Super Bowl losers this century are an awful 5-19 ATS in Week 1 (21%), including just 10-14 SU. The Super Bowl hangover is real, and it's a great spot for the Jets to come in and steal one on the road with nasty defense and a suddenly good offense with the line and QB improvements.
This line could end up rising a touch toward San Francisco since it looks like Haason Reddick is out for the Jets and Aiyuk and Williams are likely in for the Niners. Be ready to play the moment you hear Trent Williams is out, though. When Williams plays half the snaps or less, the 49ers have lost five straight games without topping 20 points, and they're 21-2 SU otherwise in that same time frame. He's the true MVP of this team and would be a huge loss.
There's not a ton of value moving up from +4.5 unless it gets to +6, so go ahead and play the Jets now. I like the moneyline too, especially if it gets near +200. J-E-T-S!
Jets vs. 49ers Spread Pick: Jets +4 (-110)
Over/Under
This total continues to drop and for good reason. Both defensive lines will have a substantial advantage over their opponent's offensive line on Monday night. And that was before we got the news that Christian McCaffrey would miss Monday's game.
For Aaron Rodgers and the Jets, the improvements up front will not translate immediately to long-developing plays or an overall aggressive nature. Expect the Jets to use max protection often, otherwise opting to get the ball out of Rodgers' hands quickly.
As for the 49ers, we cannot be certain Brock Purdy will enjoy his full complement of weapons. Brandon Aiyuk may play a limited number of snaps, Christian McCaffrey could potentially see his workload limited, and Trent Williams has barely seen the practice field.
The Jets defense travels. Games played outside of New York involving the Jets have seen the under cash at a 64.7% rate over the last two years. Furthermore, night games across the entire NFL are 17-6 to the under over the last two years in the month of September, cashing at a 73.9% rate.
I was comfortable with this line at 43.5. At 42, with the McCaffrey news, consider a half-unit, if you want to make a bet on the over/under tonight — but with the total coming back up, be sure to shop around and get the best number!
49ers vs. Jets Over/Under Pick: Under 43.5 (-110)
Monday Night Football Prop Pick
By Matt Trebby
Brandon Aiyuk joined the 49ers late in training camp after agreeing to a contract extension. Because of that, head coach Kyle Shanahan said Aiyuk would be on a reduced snap count on Monday night.
That will put even more on the shoulders of teammate Deebo Samuel.
I’m not expecting that Brock Purdy will be able to lean on Aiyuk, so I’m looking toward either George Kittle or Samuel. Well, the Jets ranked first in DVOA against opposing tight ends last season, so that mostly eliminates him.
All three players have similar receiving yard totals: Kittle 42.5, Samuel 47.5 and Aiyuk 49.5. I’m focused on who doesn’t have an awful matchup and who is going to assuredly have a normal workload.
That leads me to Samuel, who Sean Koerner’s mean projection for, as of Sunday at 1:15 p.m. ET, is 55 receiving yards.
Monday Night Football Prop Pick: Brandon Aiyuk Over 47.5 Receiving Yards (-115)
How To Watch Monday Night Football
| 49ers vs. Jets | Monday Night Football Week 1 |
| Start Time: | 8:15 p.m. ET |
| TV / Streaming: | ESPN, ABC / ESPN+, YouTube TV |
| Location: | Levi's Stadium in Santa Clara, Calif. |
Week 1 of Monday Night Football is scheduled for 8:15 p.m. ET live from Levi's Stadium on Monday. The game is live on ABC, ESPN and ESPN+ and will be available on streaming platforms, such as YouTube TV.
