The San Francisco 49ers will host the Los Angeles Rams for a Sunday Night Football showdown.
Our staff has you covered with how they're betting the spread and total.
49ers vs. Rams Picks
We've included books offering the best lines as of writing, but you can compare real-time odds here.
Chris Raybon: 49ers +2.5
The 49ers have lost outright three times as favorites — Week 1 vs. Arizona, Week 4 vs. Philadelphia, Week 5 vs. Miami — setting them up for a great buy-low spot against the Rams this week. The Rams are 4-1 but haven't truly been tested, with all of their wins coming against the NFC East — the worst division in football.
Kyle Shanahan is just 7-14-1 (33%) against the spread as a favorite but 18-13 (58%) as an underdog, and he should be able to get his team up as it plays its third straight home game, which has historically been a favorable spot for underdogs:
While the 49ers will play in their third straight home game, the Rams have already logged three trips to the East Coast, and this is a big letdown spot against their interstate rival that is getting healthier on both sides of the ball.
Despite all of their injuries on defense, the 49ers still rank third in pressure rate (30.1%), which should give Rams quarterback Jared Goff fits, as his 48.5 passer rating under pressure ranks 25th of 34 qualifiers, per Pro Football Focus.
I bet the Niners at +4 but make this game a pick 'em so would bet them down to +1.5.
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Brandon Anderson: 49ers +3
The 49ers were an absolute disaster last week. Let’s just get that out of the way right now. San Francisco got crushed 43-17 at home, and it probably wasn’t even that close. Ryan Fitzpatrick — Ryan Fitzpatrick!! — lit up this defense, and Jimmy Garoppolo was horrible in his return and got benched in favor of C.J. Beathard at the half.
Meanwhile, everyone’s riding high on the 4-1 Rams, but be careful to note where those four wins came from — the Cowboys, Eagles, Giants, and Washington Football Team. Congratulations to the Rams on winning the NFC East! Let’s see what happens when they play a real team. They’re 0-1 against non-NFC East teams, after all.
You see 4-1 vs. 2-3, and it makes sense that the Rams are favored, but the matchup is all wrong for LA. Sean McVay’s offense has been flying high again this year, but it hasn't faced the toughest competition, and it's also done it with a great rushing attack. San Francisco got killed last week in pass defense. The 49ers are quite good defending the run.
On the flip side, the Rams defense has been elite against the pass but not so good against the run, and that plays right into San Francisco’s hands. Raheem Mostert is back and fit, and the 49ers will be content to run, run, run and not put the ball in Garoppolo’s hands.
Run the ball, dominate the clock, and force Jared Goff to beat you. That’s the formula for the 49ers' success, and the formula favors San Francisco in a great bounce-back spot in front of a national Sunday night audience. Take the 49ers points, and if it drops below +3, just play the moneyline instead.
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