NFL Odds, Picks, Predictions: Your Guide To Betting Chargers-Eagles, Packers-Chiefs, Cardinals-49ers

NFL Odds, Picks, Predictions

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Chargers at Eagles Odds

Michael Arinze: This matchup sure looks like it suits the Eagles more than the Chargers. While the Chargers certainly have the motivation to snap their losing streak, the Eagles are still searching for their first win at home this season.

There are also some interesting angles working against the Chargers as they've failed to cover the spread in their last seven games played in November.

Lastly, the Chargers are 6-12 against the spread with four straight losses on the East Coast when the temperature is below 52 degrees.

When you put it all together, backing the Eagles isn't as crazy you might've thought. DraftKings has the best odds on the board as they list Philadelphia as a two-point underdog. But you'll need to hurry because that number is likely not going to hold.

Pick: Eagles +2 | Bet to: +1.5

Packers at Chiefs Odds

Joe Klein: The first rule of NFL betting is to respect the market, and both oddsmakers and bettors have given us a good bit of information this week.

With Rodgers in, most shops had this game between K.C. -1 and GB -1. As soon as he was ruled out, oddsmakers re-opened this around Kansas City -8. Bettors disagreed, and immediately smashed it down to K.C. -7, where it's sat the rest of the week. That price seems like a fair adjustment to me — having dug into Love and historical spots with new QBs, I have this game at a hair above 7.

So we turn our attention to the total, which opened around 55, was bet to 54, and re-opened at 48.

Given what Kansas City's defense brings to the table, and the system and personnel around Love, I believe Green Bay will be able to move the ball, both through the air and on the ground. And the Packers may play faster with Love than they did with Rodgers. Green Bay was bottom three in pace each year under Rodgers and LaFleur. Love played in an up-tempo system at Utah State, so I wouldn't be surprised if the Packers played a bit faster here.

This total has fallen a bit too much for my liking, but the weather conditions in Kansas City — sustained 15 mph winds, with gusts up to 28, make an over much less palatable.

There are a ton of moving pieces here, and at the end of the day, the market has settled in at K.C. -7 or -7.5 and a total of 48.  The total is a bit low to me, even when accounting for wind, but the edge is quite narrow (I project it at 49). There's a reasonable case for the over, even despite the wind, but I'm relying on subjective projections about Green Bay's increase in tempo.

Instead, I will be looking to live bet this game, in particular I'll be monitoring Green Bay's tempo and how much the wind affects downfield passing. If the Packers are playing fast and the deep ball is in play, look for a live over –particularly if the Chiefs finds themselves behind.

Pick: Live or 2H Over if either team trailing by 7+

Cardinals at 49ers Odds

Michael Arinze: We already have a great nugget on how profitable the under can be with McCoy as a starter. Here are a few more reasons to support a play on the under:

• The last three meetings between these teams have gone under the total.
• The total is 7-3 to the under in their previous 10 meetings.
• After an ATS loss, the total has gone under in Arizona's last four games.
• In Arizona's last 12 road games, the total is 10-2 to the under.

Lastly, our Action Labs database shows that under bettors are up +34.96 units in regular-season divisional games historically.

The total opened at 47, and it's now down to 45.5 at BetMGM. Provided that Murray doesn't play, I think it's playable down to 45. I'll also look to recover some of those points by playing a two-leg, six-point Wong teaser to grab the under at 51.5 and pair it with the Chiefs at -1.

Pick: Under 45.5 | Bet to 45

Bonus Pick: Two-Team Six-Point Teaser: Cardinals-49ers u51.5 and Chiefs -1

Editor's note: Previews for games that kicked off at 1 p.m. ET have been moved down in this story.

NFL Odds, Picks, Predictions

Vikings at Ravens Odds

Billy Ward: These teams combine to average exactly 50 points per game — right where the over/under is set. However, we can project a bit of an uptick for both teams here.

The pace, while not fast at first glance, meshes nicely to produce a quicker-than-average game. Both offenses are also situated nicely against the opposing defenses, with the Ravens' run game and the Vikings' pass game attacking the relative weaknesses of their opponents.

Let's take the over here, which is still 49.5 on BetMGM. Most books have moved it up to 50, which I'd still take, but no higher than that.

Pick: Over 49.5 | Bet to: 50

Patriots at Panthers Odds

Mike Randle: Even without Tom Brady as quarterback, the Patriots have gone 5-4 (55.6%) against the spread (ATS) under Belichick. Meanwhile, under Matt Rhule, Carolina is only 4-8 ATS at home and only 3-4 as a home underdog.

Last week's win against Atlanta was impressive, but it did not present the same level of challenges as the Patriots will in Week 9. If Walker starts in Darnold's place, I think this line goes to New England -4.5, which I will still gladly lay with a hot rookie quarterback and a strong defense.

Pick: Patriots -3.5 | Bet to: -4.5

Browns at Bengals Odds

Phillip Kall: We have seen Baker Mayfield excel the most with a chip on his shoulder. In his rookie season, he started as the backup and was forced to wait for his opportunity. Then, last season he was an underdog who lost his best receiver when he took his play to the next level. This year I expect the Odell Beckham Jr. drama to fuel him. The fuel may not last until the end of the year, but it should last long enough for the media to blame Beckham.

Against Cincinnati’s new pass-happy attack, Mayfield will likely be forced to throw. The Browns have played four teams that are top 10 in pass yards per game, and only the Vikings struggled to move the ball. Cleveland’s top corner, Denzel Ward, has had trouble in coverage this year, ranking 63rd, per PFF. He will likely be responsible for slowing Ja’Marr Chase, which could spell trouble.

A fired-up Mayfield and an aggressive Bengals team makes the over the angle to take.

Pick: Over 47 | Bet to: 49.5

Broncos at Cowboys Odds

Joe Klein: Denver traded Von Miller a few days ago, and the optics aren't great. The Broncos have lost four of five and have an obviously lame duck coach in Vic Fangio. Dallas is a juggernaut and just beat a borderline playoff team on the road with a backup.

So why bet the Broncos? Because the nature of this football team is to play conservative and keep the game close.

Fangio is coaching for his job, and what better way of helping his case than playing a competitive game in Dallas? The Broncos are 28th in pace and 31st in first-half pace. They play slow, limit possessions, don't make mistakes, and try to give themselves a chance at the end of games.

This defense is suspect, but the Cowboys are banged up, and we've seen no line movement for the Dallas WR injuries. While all three will likely play for the Cowboys, these type of injuries typically slow down skill players. This may give Denver's embattled secondary a better chance of keeping Dallas in check.

Bridgewater is a capable quarterback — there's a reason he's covered 70% of his games — and if Denver is down big, he certainly has the weaponry to bring the Broncos back and get into the backdoor. I price this game closer to Dallas -7.5, and at a -110 price, I'd happily take the 10 points.

Pick: Broncos +10 | Bet to: +10 (-110)

Bills at Jaguars Odds

Mike Vitanza: Given the disparities between these two teams, I expect the Bills to be able to pick their poison in this one, which means we should see a big day from Allen and the passing game.

The biggest beneficiary of this will undoubtedly be Diggs. His matchup literally could not be any better, as highlighted earlier with his 100.0 matchup advantage against this pass defense. If he sees his average of nine targets per outing, we could be looking at a ceiling game for him. In fact, if we account for the fact that he’s averaging 12.0 yards per reception, his yardage prop in this one should be in the range of 108 yards. His actual prop? 81.5 yards.

The biggest risk here is that the game gets out of hand too quickly via turnovers and/or defensive touchdowns, but the more likely scenario is an offensive outpouring by this Bills offense. Book the over with confidence ahead of what should be a monster performance from Allen and Diggs on Sunday.

Pick: Stefon Diggs Over 81.5 Receiving Yards | Bet to: 85.5

Texans at Dolphins Odds

Mike Vitanza: While rookie Davis Mills has filled in admirably-ish, this Texans offense was much more effective with Taylor behind center. Not only does his rushing upside add an extra dimension to this offense, but it also helps to open things down the field for Cooks and the rest of the receiving corps.

At the current line, the Texans are being undervalued by betting markets. In fact, sharps have already attacked the line, pushing it down from an opening of +7.5 down to its current total of +5.5. Heavy money has accompanied that shift, with 56% of tickets and 94% of the money landing on the Texans side as of the time of writing.

I’m hitting the Texans at the current line of +5.5, but I would be comfortable playing this all the way down to +4.

Pick: Texans +5.5 | Bet to: +4

Falcons at Saints Odds

Billy Ward: There's a lot of ways to approach this bet.

My expectation is that the Saints run the ball the vast majority of this game, keeping the ball away from Atlanta. When the Falcons do touch it, it's hard to see a scenario where they have much success against this Saints defense.

Since rushing attempt props aren't up yet, let's go with the Falcons team total. Under 17.5 is still available at -130 on DraftKings — 17 is an important number, so don't bet it below that.

Since we expect a lot of rushing attempts, look to bet overs on Mark Ingram. He saw six carries last week in a tight game with the pass-first Buccaneers, despite being with the team less than a week. I'd bet the over up to 9.5 if it's there.

Pick: Falcons Team Total Under 17.5 | Bet to: 17

Raiders at Giants Odds

Phillip Kall: While losing your deep threat is detrimental, the Raiders look ready to fill the void. Not only do they have Bryan Edwards who has made several key plays this year, but they also have Zay Jones. Jones may only have seven targets this year, but he has turned those into six catches for 115 yards and a touchdown. The important part for Vegas though is it still has its two top targets in Darren Waller and Hunter Renfrow.

Carr’s willingness to play patient and feed Waller and Renfrow early is what opens the deep shots in the late stages of games. While the Giants do have good corners, they will face the same problems every team has. If you focus on Waller and Renfrow, you leave your third and fourth coverage options on islands on the outside. If you focus on stopping the big plays, the Raiders will have no problem dinking and dunking their way down the field. Essentially, Carr is making the right read at the right time and making the throws to back it up.

Against an offense that is functioning as well as the Raiders, it is hard to imagine the Giants keeping up. If Golladay and Toney do suit up, they will both be less than 100%. We have even seen Toney fight through injury but then be forced out of games early. Had New York entered this game healthy, I think it could be an exciting matchup. However, they are not healthy, and Daniel Jones will constantly be under duress against the Raiders' sixth-best pressure rate per Pro Football Reference.

Back the Raiders to come out strong after the bye as they pursue the AFC’s top seed.

Pick: Raiders -3 | Bet to: -5.5