NFL Odds: Bills vs. 49ers
| Bills Odds | +1 |
| 49ers Odds | -1 |
| Over/Under | 47.5 |
| PRO Projections | Bills -1.4 | O/U: 47.4 |
| Time/Channel | 8:15 p.m. ET, ESPN |
Not only is Bills vs. 49ers game offering the biggest betting edge of tonight's NFL doubleheader, but it's also one of the top edges from NFL Week 13 overall.
By combining projected spreads and over/unders from our NFL model and comparing to the latest odds, we can quickly determine which lines are offering the smartest betting opportunities across an entire slate of games.
Using our NFL PRO Projections, let's look at the Bills vs. 49ers wager that's popping with value on Monday night.
NFL Picks: Bills vs. 49ers
The betting market sees tonight's Bills vs. 49ers game as essentially a toss up, evidenced by the 1-point spread (click here for live NFL odds).
But while San Francisco is listed at -1 across the market, our PRO Projections make Buffalo a 1.4-point road favorite in this game.
The difference between getting a the Bills at +1 and our projection of -1.4 translates into a +3.8% edge with the Buffalo spread, earning a B- grade.
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PRO Projections Pick: Bills +1
