NFL Odds: Colts vs. Broncos
| Colts Odds | +3.5 |
| Broncos Odds | -3.5 |
| Over/Under | 42 |
| Date | Thursday, Oct. 6 |
| Time | 8:15 p.m. ET |
| Channel | Amazon Prime Video |
*NFL odds as of Thursday morning
Both the Indianapolis Colts and Denver Broncos landed new starting quarterbacks over the offseason, and on Thursday Night both will be relying on their signal-callers to prevent their teams from heading into Week 6 with losing records.
NFL odds for Thursday Night Football have the Broncos as 3- to 3.5-point favorites over the Colts depending on the sportsbook, with the over/under sitting at 42.
In addition, news broke on Wednesday that Indianapolis will be without its best player, Jonathan Taylor, due to an ankle injury, which will clearly make it harder for the Colts on the offensive side of the ball.
With this in mind, what is the smartest way to bet Colts vs. Broncos on Thursday Night Football?
According to the market's sharpest NFL bettors, the answer is an easy one.
NFL Pick: Colts vs. Broncos
In the case of Colts vs. Broncos, the sharp play is the obvious play.
