The 2022 NFL Thanksgiving slate is nearly upon us, starting with Bills vs. Lions at 12:30 p.m. ET, followed by Giants vs. Cowboys at 4:30 p.m. ET and Patriots vs. Vikings at 8:20 p.m. ET.
NFL action is ingrained as a Thanksgiving tradition, making it a very popular football betting holiday as well.
NFL bettors will flood Thursday's Thanksgiving tripleheader, and the Action Network's PRO betting tools are already showing the most valuable positions to take on each of today's three games.
So let's look at the smartest Thanksgiving bets, including the NFL pick that sharps are making for Bills vs. Lions, a Giants vs. Cowboys system prediction with a 60% win rate and which Patriots vs. Vikings side experts are betting.
NFL Picks for Thanksgiving
*NFL odds as of Thursday morning
Bills vs. Lions NFL Pick
12:30 p.m. ET | CBS