NFL Picks: Week 1 Spread Predictions for Titans vs Bears, Cardinals vs Bills, More

NFL Picks: Week 1 Spread Predictions for Titans vs Bears, Cardinals vs Bills, More article feature image
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Caleb Williams #18 of the Chicago Bears runs out prior to warmups with teammates (Photo by Perry Knotts/Getty Images)

Four NFL spreads in Week 1 are right in the wheelhouse for PRO Systems.

Our proprietary models crunched the odds and submitted four NFL picks to exploit this Sunday, ranging all day: Titans vs. Bears, Cardinals vs. Bills, Panthers vs. Saints and Commanders vs. Buccaneers.

All four Week 1 games align with a specific NFL betting angle we've applied for years. The four NFL spreads are certainly worth the wager in the 2024 season opener, featuring undervalued teams with a win rate against the spread of 62% lifetime.

PRO subscribers gain access to top-notch NFL picks through various tools, expert projections, insights and more.

Having reviewed all the essential details, it's time to spotlight four NFL against-the-spread picks that bettors can exploit in Week 1.


NFL Tips: Week 1 Betting Spreads to Exploit

Early-season NFL action is the prime window to beat the market, so let's get after it.

Sunday's 62% win-rate angle is straight out of PRO Systems, designed to uncover value in spreads that may fly under the radar. The trend will pop up in future weeks with suggested picks, too.

Notice a trend among all four games that fit the PRO System in Week 1? Let me explain.

The first month or two of the NFL season still tends to bring out public biases from last season.

Our NFL betting system