NFL Predictions: Your Guide To Betting Panthers-Cardinals, Vikings-Chargers, Eagles-Broncos, Seahawks-Packers

NFL Predictions For Week 10

Panthers at Cardinals Odds

Mike Randle: There is a good chance that Murray, Hopkins or both miss this game. That would lead to a drop in the point spread on Sunday morning.

With McCaffrey fully healthy, I expect the Panthers to stay true to Matt Rhule’s promise of running the ball more. Arizona's run defense has strong metrics, but that is inflated due to the opposition usually playing from behind. Arizona is allowing a mind-blowing 130 rushing yards per game at home this season, making its 8-1 record even more shocking.

The Panthers will be highly motivated since they are just one-half game behind Atlanta for the last NFC playoff spot. Getting double-digit points against a conference rival in this spot is very enticing.

Kliff Kingsbury has not been a great bet in these situations, going just 4-7 against the spread as home favorites, per Action Labs. I'm taking the double-digit points with a Panthers team that just needs to limit the turnovers to stay competitive.

Pick: Panthers +10.5 | Bet to: Panthers +9.5

Vikings at Chargers Odds

Michael Arinze: I figured I'd wait until the conclusion to discuss the injury report because I couldn't understand why the Chargers were as high as a 3.5-point favorite at BetMGM. Both my power ratings and model projections make the Chargers no more than a 2.5- to 2.75-point favorite.

However, the three players on the Vikings' injury report are all starters. Breeland certainly could play, considering he was a limited participant in practice this week. Barr and Pierce are already ruled out, meaning each level of the Vikings defense will be dealing with an injury.

As for the Chargers, their most significant issues are in the secondary, with starting cornerback Michael Davis doubtful and backup cornerback Ryan Smith done for the season (ACL). Though, they will get Asante Samuel Jr. back as he's now out of the concussion protocol.

When you factor in the injuries on both sides, I can understand the line moving in favor of the Chargers. However, Armon Watts and Blake Lynch could step in to replace Barr and Pierce. Both Watts and Lynch have a higher PFF grade this season than Barr and Pierce.

Thus, I'm not sure I'm ready to fade Mike Zimmer, who's 70-49-1 ATS for +17.17 units. Furthermore, when Zimmer's on a two-game losing streak, he is 11-3 ATS for 7.19 units.

This could be the absolute last stand for Zimmer and the Vikings, so give me the 3.5 points with the road underdog.

Pick: Vikings +3.5 | Bet to +3

Eagles at Broncos Odds

Phillip Kall: It is tough to take a side in this one as each team has shown high highs and low lows. However, the total should have some value in it.

The Eagles offense is run first and should keep the clock moving. We have seen the Eagles simply run up and down the field on opponents in recent weeks, but I doubt Vic Fangio allows that. We saw the Broncos force Dallas away from the run, and I expect them to make Hurts beat them. While Hurts has been excellent for fantasy, he typically pads his numbers in garbage time. I doubt Denver gets that kind of lead in this game.

For Denver, I believe we saw the apex of what they can be last week. The result was a 30-point outing. Even though the Broncos played near-perfect offensively, their drives were methodical and ate the clock. The conservative style does match Denver's personnel and increases its chances of winning, but not necessarily its points scored.

Trust both teams to rely on their revamped offenses and keep the scoring low.

Pick: Under 45.5 | Bet to: 44

Seahawks at Packers Odds

Billy Ward: After opening at 51, the total in this game has fallen two to three points depending on the book and despite encouraging news surrounding the quarterbacks. Still, there's value to be found on the under.

Simply put, there are far more scenarios in which this game is a slog than a shootout. Even with both Rodgers and Wilson playing, there are questions about Wilson's effectiveness after returning from a broken finger so quickly.

Both teams also prefer to play slow, running football as long as they can. While this game will eventually open up offensively, it will likely happen late enough into the afternoon for the under to be assured.

The totals being offered by books now are probably a realistic mean scenario if this game were to be played 100 times. Some handful of those games would absolutely be a shootout, with both passing offenses lighting up the scoreboard.

However, the median expectation of this game falls short of the current number. With all the ways this game could fail to produce points, it's the better bet.

Pick: Under 49 | Bet to: 49

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Editor's note: Previews for the 1 p.m. ET games are below.

NFL Predictions For Week 10

Falcons at Cowboys Odds

Michael Arinze: There's a decent chance that this line continues to move based on the news that Cowboys LT Tyron Smith and DE Randy Gregory are ruled out. However, the Falcons shouldn't be slighted, given how Matt Ryan is playing above expectations thus far this season.

Atlanta has also had success against Dallas as the Falcons are 4-1 against the spread (ATS) over the last five meetings between these two teams, per our Action Labs data. And if we look at how Dallas has performed off a loss when it's at least a nine-point favorite, it's just 2-8 ATS for -6.03 units.

To summarize the argument detailed in the full preview, the Falcons are worth a look in this spot, so I'll look to play them at +8.5 or better. (Note that PointsBet is still offering +8.5 as of writing, but you can shop for the best real-time line at any point here.)

Pick: Falcons +8.5 | Bet to: +8.5

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Jaguars at Colts Odds

Mike Vitanza: While the rankings suggest the Jaguars should find a good deal of success moving the ball against this 26th-ranked Colts pass defense, the reality of this Jacksonville team is that it can’t seem to hang onto the ball long enough to turn many of its successful drives into points. Against a Colts team that is near the top of the league in turnover differential, we’re likely to see very few points from the Jaguars here.

While the Colts offensive matchup is strong and I do expect a solid performance here, they do tend to slow things down a bit when they jump out to a sizable lead. In fact, when leading by 7+ points, their 31.4 seconds per play is sixth-slowest in the entire lead.

At a relatively high total of 47.5 points, there is value on the under. In fact, this total has been dropping all week. It started as high as 51 points, but sharps have pushed it all the way down to the current number. I still like it at 47.5, but I would play it down to 47 if the line continues to move before kickoff.

Pick: Under 47.5 | Bet to: Under 47

Browns at Patriots Odds

Joe Klein: Cleveland's numbers don't tell the full story this year, and we as bettors are the beneficiary. This team is due for positive regression on both offense and defense, and the injury report is as good as it's been in several weeks.

The Browns have advantages all over the defense. Their offensive line remains a juggernaut, so Mayfield won't have to do much in order for Cleveland to get it done here. And in-game decision making? Kevin Stefanski is one of the best at going for it on fourth down when he should. As for Bill Belichick, he is dead last so far in terms of win probability lost by punting instead of going for it. In a tight, physical game, one extra possession may be the difference.

Home-field advantage has been chronically overvalued this season in the market, with home teams winning on average by less than half a point in 2021. New England has some home-field advantage, but even with a conservative advantage, I have Cleveland as a favorite.

The Browns have the formula to finish off a game with a lead. I prefer them on the moneyline over the spread here, but I don't fault anyone for splitting the two.

Pick: Browns ML +120 | Bet to: -105

Bills at Jets Odds

Mike Vitanza: Assuming the Bills can put last week’s poor performance behind them, I expect this offense to regain form and remind everyone why they were an early-season Super Bowl favorite.

When this team has excelled in similar scenarios in the past, it’s been largely through the air. As the top receiving option with a plus matchup, we could be looking at a potential ceiling game for Diggs here.

If you read the Bills-Jaguars Week 9 game guide, you’ll remember I was on this same prop. Even in what turned out to be the worst-case scenario, Diggs came through and hit the over on his 81.5 yardage prop. This week, oddsmakers have inexplicably lowered his prop to 76.5 yards in an even better spot.

The targets will be there, the matchup is pristine and the Bills will be looking to make a statement. Once again, give me the over on this Diggs receiving prop.

Pick: Stefon Diggs Over 76.5 Receiving Yards | Bet to: 84.5

Lions at Steelers Odds

Editor's Note: This preview was written before news broke that Ben Roethlisberger would reportedly be placed on the reserve/COVID-19 list and miss Sunday's matchup.

Joe Klein: There's some love in the market this weekend for the Lions, and I understand why. Only five of the Steelers' 16 wins since the start of last season have come by more than one score. And remarkably, every single Pittsburgh drive this season when the Steelers have led by 14 points or more has resulted in a three and out. That stems from Tomlin's general conservative approach.

I can't touch this Detroit team with a 10-foot pole when Goff is outdoors in potentially bad weather. But the Steelers' wide receiver injuries, coupled with a potentially healthier Lions' secondary, make me more bearish on Pittsburgh's offensive output Sunday.

Better numbers on this total were available on Monday and Tuesday, but this is still an under look for me. I don't mind the Steelers' team total under either, but getting to fade Goff outdoors is too much to pass up.

Pittsburgh also presents a good teaser option, going from -8 to -2.

Editor's Note: This pick was made before news that Roethlisberger would miss Sunday's game.

Pick: Under 43 | Bet to: 41.5

Saints at Titans Odds

Editor's Note: This preview was written before the Titans placed Julio Jones on the injured reserve.

Phillip Kall: Against the Saints, the Titans should face similar troubles to what the Rams presented. Good run defenses will force them to throw and New Orleans’ top corner will follow Brown. Fortunately, they do have the additional playmaking threat in Jones. We have only seen Jones be a big contributor against Seattle this year, but he did play a key role in their comeback attempt last week.

As for the Saints offense, we saw them struggle for three quarters against a woeful Falcons defense. Now, New Orleans will have to overcome a better defense without its best offensive weapon. I know Sean Payton is an offensive genius and the Saints play to their competition, but at some point injuries are too much.

When it comes down to it, I believe in the Titans to force Siemian to beat them and that the Saints have no answer for Jones. Take the Titans to extend their lead in the AFC.

Editor's Note: This pick was made before the Titans placed Jones on the injured reserve.

Pick: Titans -2.5 | Bet to: -4

Buccaneers at Washington Odds

Billy Ward: Three times this year, Tampa Bay has played against bottom-10 defenses by DVOA. In those three games, they've averaged over 40 points, with a low of 28.  Tampa has been favored by at least nine points four times this year — they've averaged over 40 points in those games, too (with a low of 31). Both of those scenarios are at play here.

Unlike many teams, the Bucs don't let up and run out the clock, they keep passing regardless of the score. Thus, we can confidently bet on their team total without fear of a blowout suppressing it.  I like the Bucs' alternate total of over 34.5 on BetMGM. It's currently +155, which implies a sub-40% probability.

Make sure Chris Godwin is good to go before making this bet though. Tampa has shown an ability to function offensively down one of their three starting wideouts, but losing two might be too much to overcome.

Pick: Bucs Team Total Over 34.5 | Bet to: +150