Giants vs 49ers Spread Pick: Thursday Night Football’s Profitable ATS Prediction

Giants vs 49ers Odds

*NFL odds as of Thursday afternoon

Being a New York Giants fan is exhausting.

First, the GMEN got absolutely pummeled by the Dallas Cowboys in Week 1.

Then one of the largest comebacks in NFL history was needed to beat the tanking Arizona Cardinals by three points.

Like I mentioned, exhausting.

Looking at live NFL odds for Giants vs. 49ers doesn't provide much hope either, as San Francisco is a massive 10-point favorite heading into Thursday Night Football.

This game could turn into Blowout City, which means I might be able to go to bed early, at the very least.

And while I'm nervous as a fan, there's much less confusion regarding the smartest NFL prediction for Thursday Night Football.

Let me explain.

Giants vs 49ers Spread Pick