Three underdogs don't need the points on Sunday of NFL Week 1. We've bookmarked a trio of sides primed for an upset right out the gates.
PRO Systems feature a backtested system (22% ROI) strictly for NFL upset predictions. The trend already highlighted several Week 1 NFL matchups in which betting the underdog to win outright is a smart play for Sunday.
The top NFL upset picks for Week 1 from our premium PRO System consider factors like spread range, over/under, division and more.
The best time to capitalize on this angle is early in the season, when team strengths are still uncertain.
These are the top betting choices to pull off an upset in Week 1, supported by nothing but reliable data.
NFL Upset Predictions, Moneyline Picks for Week 1
It's fun to root for upsets.
However, don't just blindly throw darts at plus-money picks for NFL Sunday; there's a certain method to picking the best NFL upsets, and our PRO System guides us to a handful of worthwhile moneyline predictions.