NFL Week 5 Odds, Predictions: Every Single Sunday Afternoon Game Covered

NFL Week 5 Picks

All odds as of 4:15 p.m. ET on Saturday afternoon.

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Lions vs.

Patriots

Odds via FanDuel. Get up-to-the-minute NFL odds here.

Kody Malstrom: I thought the injuries to Detroit's playmakers may mean a step back, but the Lions still shredded the Seahawks defense. The injuries are similar this week and the game should be no different. The Patriots don't provide a much higher step up in defensive success compared to Seattle.

As for New England, I was thoroughly impressed with how efficiently it moved the ball with rookie Bailey Zappe coming in the middle of the game against the Packers. The Patriots offense is in good position to produce again if the rushing attack thrives and gives Zappe momentum to build off.

Lions overs is the theme once again, assuming we will be witnessing another shootout. If Zappe is going to burn the Lions fan in me, the least he can do is put up points to hit the over.

FanDuel Quickslip: Over 45.5 | Bet to 48.5

Steelers vs.

Bills

Odds via FanDuel. Get up-to-the-minute NFL odds here.

Landon Silinsky: The Bills should be able to hit their team total relatively easy here, and there could also be quite a bit of garbage time.

I expect Kenny Pickett to make plenty of mistakes in this game, leading to short fields for Buffalo, but the rookie does have plenty of weapons to work with and there can potentially be splash plays from the Pittsburgh offense in this spot, especially if the game gets out of hand and Buffalo backs off a bit.

Laying 14 points in the NFL is always tough to do no matter how good the favorite is, so a nice way to hedge is to take over 46.5 total points and hope the Steelers score in garbage time.

FanDuel Quickslip: Over 45.5 | Bet to 47

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Dolphins vs.

Jets

Odds via FanDuel. Get up-to-the-minute NFL odds here.

Blake Krass: I think these two teams are more well-matched than the public thinks, especially with Teddy Bridgewater at the helm. The Dolphins could struggle to replicate the explosive plays they have relied on and their defense is susceptible to giving up big plays.

Zach Wilson should perform well in his return to MetLife and the bolstered Jets' OL should help him find his plethora of skill position options. The athleticism of the Jets' defense should also keep the Dolphins' weapons at bay.

The Jets should keep this game close and this could come down to a field goal in either direction, in which case I lean toward New York's superior special teams. I like the Jets at a field goal or better and think they have a good chance to win outright.

FanDuel Quickslip: Jets +3.5 | Bet to +3

Falcons vs.

Buccaneers

Odds via FanDuel. Get up-to-the-minute NFL odds here.

Anthony Dabbundo: The loss of Kyle Pitts is a major reason why the line moved further toward Tampa, but it seems like an overreaction to me.

Tampa Bay's offense wasn't nearly effective enough over the first three weeks of the season for me to buy in on them as a double-digit favorite against a team that has shown to be more than competent offensively.

While you would think that teams 4-0 ATS in Week 5 would be naturally inflated the following week, that's not been the case. Atlanta is the 28th team in the last 20 years to start 4-0 ATS, and those teams are 13-13-1 ATS in Week 5, per our Action BetLabs system. None of those squads have closed higher than +4.5.

The trends surrounding Tom Brady point to betting Tampa in this spot. He's 8-2 ATS in his career off multiple losses and there's no denying this is a good get-right spot.

I just can't get to the number where Tampa Bay is a double-digit home favorite and I will take the Falcons +9 or better.

Pick: Falcons +10 | Bet to +9

Seahawks vs.

Saints

Odds via FanDuel. Get up-to-the-minute NFL odds here.

The Great Foosini: Here's what we know: Seattle tends to give up a ton of yards. That is going to happen this week, and most weeks moving forward. The Saints should finally be able to translate that YPP differential into actual points, just as every opponent Seattle has faced has done.

We also know the Saints play close games, and do not function well as a favorite. Seattle has played as an underdog between 3.5 and 6.5 points twice this year, winning outright each time.

While I do not expect Geno Smith to win this game, it is certainly possible with Andy Dalton at the helm plus the Saints' tendency to underachieve. New Orleans' game against the Falcons provides a nice corollary to this matchup, and I expect a similar result.

My prediction is New Orleans 26, Seattle 23, so I will be taking both the over and Seahawks with the points at 5.5.

Pick: Over 45.5, Seattle +5.5 | Bet to Over 46, Seattle +5.5

Texans vs.

Jaguars

Odds via FanDuel. Get up-to-the-minute NFL odds here.

Phillip Kall:Coming into the year, the Jaguars were a sneaky fun pick to win the AFC South and have lived up to the hype. Even at 2-2, the Jaguars rank third in point differential at +38 and are currently tied for the division lead. The offense has been balanced and is thriving, and it could've done better last week against the Eagles with reasonable weather.

Houston, on the other hand, has played as you would hope a rebuilding team would. Each week some young players flash and provide optimism for the future. The Texans remain competitive in games so fans don’t rebel against the organization.

While Houston has kept games close, its bend-but-don’t-break defense might be meeting its match. Jacksonville’s biggest problem has been getting the ball rolling on drives, ranking 20th in total yards. Once it gets rolling, though, good things happen, which has them at sixth in points scored. 

Jacksonville will recover after a tough loss in Philly and show their point differential is no fluke.

FanDuel Quickslip: Jaguars -7 | Bet to -7.5

Titans vs.

Commanders

Odds via FanDuel. Get up-to-the-minute NFL odds here.

Dylan Wilkerson:The Titans have made it clear they do not mess around early in the game. When they're able to follow their pregame script, they march down the field with seemingly no opposition.

This all changes after halftime for Tennessee. Three scoreless second halves this season is a trend that I can not ignore.

As unappealing as it may seem, I will be putting my full trust in Carson Wentz & Co. late in this game.

Pick: Commanders 2H ML (+100) | Bet to -110

Bears vs.

Vikings

Odds via FanDuel. Get up-to-the-minute NFL odds here.

Sam Farley: One of Kirk Cousins' pass catchers who hasn't really erupted this season is Irv Smith Jr., with the tight end having only earned 91 yards through four games, although he has found the end zone once.

Big things were expected of the former Alabama man when he was drafted in the second round of the 2019 NFL Draft, but despite effectively being a wideout with a tight end designation, he hasn't really become the threat they'd have hoped.

Now he faces a Bears defense with the seventh best record against tight ends, allowing just 134 yards to the position so far this season. His line sits at 26.5 receiving yards for this game, a number he's only exceeded twice this year, both times marginally. For that reason I'm backing Smith's under.

FanDuel Quickslip: Irv Smith Jr. Under 26.5 Receiving Yards | Bet to 26.5

Chargers vs.

Browns

Odds via FanDuel. Get up-to-the-minute NFL odds here.

Sam Farley: No man embodies the Browns' identity more than Nick Chubb. Last season, he was second in rushing yards across the league behind Jonathan Taylor and now he trails only Saquon Barkley, who Chubb trails by just four yards.

Chubb leads the NFL with 15 runs of 10-plus yards, which are more than 25 NFL teams, and he's forced 32 missed tackles on rushes this year, 10 more than his nearest rival.

Chubb didn't find the end zone in Week 1, when the Browns struggled to beat the Panthers, but since then he has been unstoppable. Chubb has five touchdowns in his last three games.

Chubb is -125 to score again on Sunday, which looks like a great price given his dominance and importance to the team.

Dameon Pierce, James Robinson, Jerick McKinnon and Brandon Bolden have all scored against the Chargers this season, and Chubb should add his name to that list.

FanDuel Quickslip: Chubb Anytime Touchdown (-125)

49ers vs.

Panthers

Odds via FanDuel. Get up-to-the-minute NFL odds here.

Cody Goggin:While I believe that San Francisco’s offensive struggles could come into play here and lead this game to the under, I also think that there is always potential for a blowup game for them against a bad team. In a positive game script where they will more than likely be running the ball a lot, Kyle Shanahan’s offense is capable of breaking off some big runs that could run up the score.

Because of the potential for a San Francisco blowout, this pulls me away from taking the under in the game and instead I will be taking the Niners to cover as I don’t see a route to Carolina having even a moderate amount of offensive success. DeMeco Ryans’ defense should be suffocating and could even lead to this being the final game that Matt Rhule coaches in Charlotte.

As of Saturday afternoon, the only book offering 49ers -6 was PointsBet. Everywhere else was -6.5. Follow our live NFL odds page to get the best number before kickoff.

Pick: 49ers -6 | Bet to -7

Cowboys vs.

Rams

Odds via FanDuel. Get up-to-the-minute NFL odds here.

Anthony Dabbundo: I have question marks about both offenses coming into this game. Cooper Rush has major regression coming in the turnover department and is likely to be under duress in passing downs for the majority of this game. Stafford could also face plenty of pressure, and given Dallas's elite short pass defense, there's a concern for the Rams offense running into some problems.

But the number is too short now because of the Rams' road loss to San Francisco.

The Rams always seem to lose to the 49ers and often look bad doing so. Niners head coach Kyle Shanahan has owned Rams coach Sean McVay in their rivalry. But McVay always has the Rams ready to play the following week. They've followed five or their last six losses to the 49ers with wins and covers the following week.

Given that the lookahead line for this game was seven and nothing happened last week to change my opinion of either team, it's time to sell high on the Rush revolution and take the Rams at the shorter price.

I wouldn't lay more than six points in this matchup because of backdoor risk and six being a key number.

Click Here to Bet Rams -5.5 on FanDuel | Play to Rams -6

Eagles vs.

Cardinals

Odds via FanDuel. Get up-to-the-minute NFL odds here.

John LanFranca:The Kliff Kingbury underdog narrative has some merit, but when you look a little deeper, you discover he actually has a losing record (5-6) against the spread in his home stadium when he is catching points.

The Cardinals have to play completely mistake-free football to even have a chance. They do not have the talent on the back-end to slow down A.J. Brown and DeVonta Smith, and more importantly, they do not have the players up front to bother Jalen Hurts.

I have no doubt that some sharp bettors will grab the illusion of value with Arizona and the points in this game; it’s a mistake that will keep the spread under the key number of seven. No need to overthink this matchup, the Eagles will move to 5-0 in convincing fashion.

Pick: Eagles -5 | Bet to -6