NFL Week 5 Predictions, Spread Picks

NFL Week 5 Predictions, Spread Picks article feature image
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Aaron Rodgers #8 of the New York Jets (Photo by Michael Owens/Getty Images)

As we dive into our NFL Week 5 predictions, we're utilizing advanced techniques — such as PRO Systems and cutting-edge insights from PRO Report — to identify the best bets and spread picks.

Although it's early in the betting cycle, there are already some intriguing opportunities to consider when analyzing Action PRO models.

We've pinpointed four key signals — sharp action, big money, systems and expert opinions — that are aligning for a promising pick in the Panthers vs. Bears matchup.

Additionally, there's an intriguing game on the other side of the Atlantic, where the Jets will take on the Vikings in London. This particular game is noteworthy as it fits into a highly successful situational angle, which boasts a 61% win rate, that has been particularly effective when going against public sentiment.

Now, let’s break down a couple of sharp picks to assist bettors in making informed decisions for NFL Week 5.


NFL Week 5 Predictions, Spread Picks

Jets vs. Vikings Prediction for Week 5

Jets Logo
Sunday, Oct 6
9:30 a.m. ET
NFL Network
Vikings Logo
Jets Odds
SpreadTotalMoneyline
+2.5
-105
40.5
-110o / -110u
+124
Vikings Odds
SpreadTotalMoneyline
-2.5
-115
40.5
-110o / -110u
-148
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo

We start with the showdown in London between the Jets and Vikings, an early international matchup that presents a unique betting opportunity.

The key situational angle here is captured by the PRO System dubbed