Both the spread and over/under are attractive bets to make in the early window when the Carolina Panthers and Buffalo Bills square off Saturday at 1 p.m. ET.
It's better late than never for Bryce Young and the Panthers' starters, who are scheduled to see action for the first time this preseason.
On the flip side, the Bills are resting their starters. The Bills' quarterback room will look a whole lot different Saturday for Week 3.
Josh Allen will sit and Mitchell Trubisky is out with injury. Therefore, Ben DiNucci and the recently signed Anthony Brown will take snaps for the Bills vs. the Panthers at HighMark Stadium.
The Panthers are favored by 4.5 points — an uncommon scenario that would likely flip in favor of Buffalo during the regular season. Moreover, the Panthers vs. Bills over/under Saturday features the lowest total of the preseason and is drawing particular attention from savvy bettors.
Taking our NFL experts' opinions and combining them with our PRO insights, let's transition to valuable Panthers vs. Bills spread and over/under picks for Saturday.
Panthers vs. Bills Spread, Over/Under Best Bets for August 24
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