Patriots vs 49ers Picks, Odds, Predictions for NFL Week 4

Patriots vs 49ers Picks, Odds, Predictions for NFL Week 4 article feature image
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Fred Warner #54 of the San Francisco 49ers (Photo by Michael Zagaris/San Francisco 49ers/Getty Images)

PRO Report shows a smart bet for Sunday of NFL Week 4, featuring two teams off weird losses.

The San Francisco 49ers, coming off an upset loss to the Rams, are now 1-2 on the season, the same record held by the New England Patriots, who were soundly defeated by a 21-point margin last week.

Sunday's NFL showdown between the Patriots and 49ers boasts two teams with stark contrasts. The 49ers, out of the NFC, are expected to contend. The rebuilding Patriots, meanwhile, travel from the east out of the AFC.

Scheduled to kick off at 4:05 p.m. ET at Levi's Stadium, this game has plenty on the line for both teams.

With the 49ers favored by a hefty -10.5 points and the game total set at 40.5, this preview dives into various betting prospects including the spread, moneyline, and totals.

Patriots vs. 49ers Odds, Picks, Predictions

Patriots Logo
Sunday, Sep 29
4:05 p.m. ET
FOX
49ers Logo
Patriots Odds
SpreadTotalMoneyline
+10.5
-110
40.5
-110o / -110u
+450
49ers Odds
SpreadTotalMoneyline
-10.5
-110
40.5
-110o / -110u
-550
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo
  • Patriots vs. 49ers spread: 49ers -10.5
  • Patriots vs. 49ers over/under: 40.5
  • Patriots vs. 49ers moneyline: Patriots +450, 49ers -550

Spread

The 49ers are -10.5 vs. the Patriots. San Francisco has been favored in all four games.

Over/Under

The over/under is set at 40.5 points, with each side marked at -110.

Moneyline

The Niners' -550 moneyline is the largest of Week 4. The Patriots are listed at +450 to pull off the upset.

Player Prop

Rhamondre Stevenson's rush yards over/under is 54.5. PRO Projections make the fair line more like 59.

Patriots vs. 49ers Prediction

There's a smart way to bet the game, utilizing PRO resources, specifically sharp and big-money signals.

Point Spread

Firstly, the “Bet Against Public After Bad Game (PRO)” System is activated, favoring the Patriots with a 61% win rate and an 18% ROI. This profitable system suggests that betting on the Patriots to cover the spread after a poor performance might yield positive results. Additionally, we've tracked sharp action on the 49ers, indicating that professional bettors see value in San Francisco covering the spread.

Total

For the total, the analysis is clear-cut.

The game falls under the Big Money classification for the