Patriots vs. 49ers Odds Spread, Over/Under for NFL Week 4

Patriots vs. 49ers Odds Spread, Over/Under for NFL Week 4 article feature image
Credit:

Getty Images. Pictured: Jacoby Brissett and Brock Purdy

Patriots vs 49ers Odds for NFL Week 4

Patriots Logo
Sunday, Sep 29
4:05 p.m. ET
FOX
49ers Logo
Patriots Odds
SpreadTotalMoneyline
+10
-110
39.5
-110o / -110u
+390
49ers Odds
SpreadTotalMoneyline
-10
-110
39.5
-110o / -110u
-525
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

The Patriots (1-2) face the 49ers (1-2) in Week 4 of the NFL season with kickoff set for 4:05 p.m. ET at Levi's Stadium in Santa Clara, California. Here's an early look at the Patriots vs. 49ers odds, spread and total for this Sunday afternoon matchup.

The 49ers are favored by 10.5 points over the Patriots in the latest NFL odds for Week 4, with the over/under set at 40.

New England Patriots

New England was feisty over the first two weeks of the season, upsetting the Bengals before falling to the Seahawks in overtime. However, the Patriots no-showed in a Thursday Night Football clash against the rival Jets.

New England’s defense has been relatively stout, especially against the run, as it's given up the eighth-fewest yards per game (83.0). The Patriots enter the game as an underdog for the fourth-straight time to start the year.

San Francisco 49ers

The banged-up 49ers blew a 10-point lead with just over six minutes remaining against the Rams in a gut-punch loss.

The offense managed to put up points despite Christian McCaffrey, Deebo Samuel, George Kittle and Ricky Pearsall out injured. However, the defense couldn’t get enough stops against an equally decimated Rams offense.

Patriots vs 49ers Picks

About the Author
Ricky Henne writes for the Action Network's news team, covering all sports, events and breaking news. He also contributes to Action's NFL coverage. Ricky joined Action in 2022 with more than 20 years of experience covering professional sports. He wrote for the Los Angeles Chargers, New York Knicks and New York Rangers before entering the sports betting industry.

Follow Ricky Henne @rickyhenne on Twitter/X.

This site contains commercial content. We may be compensated for the links provided on this page. The content on this page is for informational purposes only. Action Network makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event.