Saints vs Chiefs Picks, Odds, Spread: Monday Night Football Predictions

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Xavier Worthy #1 of the Kansas City Chiefs celebrates a touchdown with teammate JuJu Smith-Schuster #9 (Photo by Christian Petersen/Getty Images)

Three key PRO signals all agree on where the value is at for Monday Night Football.

NFL's Week 5 prime-time tilt features the New Orleans Saints traveling to Kansas City to take on the undefeated Chiefs for a 8:15 p.m. kick.

This game will highlight some of the league's most electrifying talents, with Chiefs quarterback Patrick Mahomes and tight end Travis Kelce aiming to continue their win streak.

The Saints, with a 2-2 record, will rely heavily on star running back Alvin Kamara to challenge the Chiefs' perfect start. As we dive into betting angles, the Chiefs are favored by 5.5 points, with the over/under set at 43 points.

Monday Night Football is also a non-conference clash featuring two teams that don't play each other very often. Here's the smart way to play it.

Saints vs. Chiefs Odds, Picks, Predictions

Saints Logo
Monday, Oct 7
8:15 p.m. ET
ESPN
Chiefs Logo
Saints Odds
SpreadTotalMoneyline
+5.5
-110
43
-110o / -110u
+205
Chiefs Odds
SpreadTotalMoneyline
-5.5
-110
43
-110o / -110u
-250
Odds via Caesars. Get up-to-the-minute NFL odds here.
Caesars Logo
  • Saints vs. Chiefs spread: Chiefs -5.5, -110 | Saints +5.5, -110
  • Saints vs. Chiefs over/under: o43, -111 | u43, -110
  • Saints vs. Chiefs moneyline: Chiefs -250 | Saints +202

Spread

As the Chiefs aim to defend their unblemished record, they are favored by 5.5 points with odds of -110.

Over/Under

The over/under is set at 43 points.

Moneyline

The moneyline is set at Chiefs -250, Saints +202.

Player Prop

PRO Projections peg Saints QB Derek Carr's passing yards at 215 – slightly higher than the line of 208.5.

It's only a +1.6% edge. PRO Projections recommend a 3.5% or better when tailing, so this one doesn't exactly meet the criteria.

Saints vs. Chiefs Prediction

Split opinions surround the Monday Night Football spread. Two of our top NFL experts, representing a 100% consensus, are backing the Saints to cover. Conversely, sharp action has emerged on the Chiefs, indicating contrasting perspectives among seasoned bettors.

Total

The sharpest Chiefs vs. Saints pick in PRO Report at the time of writing is