NFL preseason Week 2 action offers an intriguing Saints vs. 49ers prediction that's catching the attention of sharp bettors for when the teams meet in the Bay Area on Saturday.
According to our PRO Report, both Sharp Action and Big Money signals align on a specific pick for the NFC exhibition. The Saints are listed as small favorites, and the over/under is set between 38 and 38.5, depending on the shop, marking one of the higher totals for Week 2.
Backups Jake Haener and Spencer Rattler highlight the Saints quarterback room, while Josh Dobbs and Brandon Allen split time in the 49ers opener.
With these factors in play, let’s dive into the Saints vs. 49ers prediction bringing in some interesting betting activity Saturday.
Saints vs. 49ers Prediction & NFL Preseason Odds
| Saints Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1 -125 | 38 -110o / -110u | -108 |
| 49ers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1 +105 | 38 -110o / -110u | -112 |
Sharps Making Bold Saints vs. 49ers Prediction
Both the Saints and 49ers failed to cover the spread in Week 1, and both teams went under the total.
Despite those trends, sharp bettors are making a bold prediction by targeting Over 38 for Saturday night's tilt. The betting data reveals that while only 38% of the tickets have landed on the over, the bets overall comprise a substantial 51% of the money. This usually indicates that the smarter, bigger players are predicting a higher-scoring game than the market anticipates.
The Saints-49ers over/under being as high as 38.5 may seem high after both teams' performances last week, but PRO Report clearly leans toward an offensive showcase this Saturday and that's driven by smart money.
The preseason can produce juicy edges that boost the efficacy of PRO signals. Sharp bettors possess a more profound knowledge of reserves, who usually play more in preseason.
PRO Report Over/Under Pick for Saints vs. 49ers: Over
Our PRO signals flag far more great picks than our staff could author each day — that's where Action AI comes in. Using generative AI, signals that hit a high-grade threshold are written up into articles that are then vetted and edited by a human to help us get you all the sharp action. Read more about how it works here.
