Favorites went 6-6 against the spread while overs went 8-4 on the first NFL Sunday of the 2020 season (excluding Sunday Night Football). So what can we expect heading into Week 2?
Books are already rolling out their opening lines. You'll find spreads and totals for every game, starting with the Thursday Night Football matchup between the Bengals and Browns and ending with the Monday Night Football showdown between the Saints and Raiders.
Week 2 NFL Odds: Spreads & Totals
Odds as of 8 p.m. ET on Sunday and via DraftKings. Get up to a $1,000 sign-up bonus at DraftKings today or see more offers and reviews for the best online sportsbooks.
Cincinnati Bengals at Cleveland Browns
Thursday Night Football
- Odds: Browns -6.5 [BET NOW]
- Over/Under: 45.5 [BET NOW]
- Time: 8:20 p.m. ET on Sept. 17
- TV Channel: NFL Network
San Francisco 49ers at New York Jets
- Odds: 49ers -6.5 [BET NOW]
- Over/Under: 43.5 [BET NOW]
- Time: 1 p.m. ET on Sept. 20
- TV Channel: FOX
Buffalo Bills at Miami Dolphins
- Odds: Bills -4 [BET NOW]
- Over/Under: 42.5 [BET NOW]
- Time: 1 p.m. ET on Sept. 20
- TV Channel: CBS
Detroit Lions at Green Bay Packers
- Odds: Packers -5.5 [BET NOW]
- Over/Under: 46 [BET NOW]
- Time: 1 p.m. ET on Sept. 20
- TV Channel: FOX
Minnesota Vikings at Indianapolis Colts
- Odds: Colts -3 [BET NOW]
- Over/Under: 46 [BET NOW]
- Time: 1 p.m. ET on Sept. 20
- TV Channel: FOX
Carolina Panthers at Tampa Bay Buccaneers
- Odds: Buccaneers -8 [BET NOW]
- Over/Under: 48.5 [BET NOW]
- Time: 1 p.m. ET on Sept. 20
- TV Channel: FOX
Los Angeles Rams at Philadelphia Eagles
- Odds: Eagles -2.5 [BET NOW]
- Over/Under: 48.5 [BET NOW]
- Time: 1 p.m. ET on Sept. 20
- TV Channel: FOX
Jacksonville Jaguars at Tennessee Titans
- Odds: Titans -10.5 [BET NOW]
- Over/Under: 42.5 [BET NOW]
- Time: 1 p.m. ET on Sept. 20
- TV Channel: CBS
Atlanta Falcons at Dallas Cowboys
- Odds: Cowboys -7 [BET NOW]
- Over/Under: 50.5 [BET NOW]
- Time: 1 p.m. ET on Sept. 20
- TV Channel: FOX
Denver Broncos at Pittsburgh Steelers
- Odds: Steelers -6.5 [BET NOW]
- Over/Under: 43 [BET NOW]
- Time: 1 p.m. ET on Sept. 20
- TV Channel: CBS
New York Giants at Chicago Bears
- Odds: Bears -5.5 [BET NOW]
- Over/Under: 43 [BET NOW]
- Time: 1 p.m. ET on Sept. 20
- TV Channel: CBS
Washington Football Team at Arizona Cardinals
- Odds: Cardinals -6.5 [BET NOW]
- Over/Under: 46 [BET NOW]
- Time: 4:05 p.m. ET on Sept. 20
- TV Channel: FOX
Kansas City Chiefs at Los Angeles Chargers
- Odds: Chiefs -7 [BET NOW]
- Over/Under: 50.5 [BET NOW]
- Time: 4:25 p.m. ET on Sept. 20
- TV Channel: CBS
Baltimore Ravens at Houston Texans
- Odds: Ravens -6.5 [BET NOW]
- Over/Under: 53.5 [BET NOW]
- Time: 4:25 p.m. ET on Sept. 20
- TV Channel: CBS
New England Patriots at Seattle Seahawks
Sunday Night Football
- Odds: Seahawks -3.5 [BET NOW]
- Over/Under: 44.5 [BET NOW]
- Time: 8:20 p.m. ET on Sept. 20
- TV Channel: NBC
New Orleans Saints at Las Vegas Raiders
Monday Night Football
- Odds: Saints -5.5 [BET NOW]
- Over/Under: 50.5 [BET NOW]
- Time: 8:15 p.m. ET on Sept. 21
- TV Channel: ESPN
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