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NFL Predictions, Odds for Every Game: Week 2 NFL Schedule

NFL Predictions, Odds for Every Game: Week 2 NFL Schedule article feature image
NFL
Credit:

Getty Images. Pictured: An NFL football during the 2024 season.

Our experts have taken a look up and down the NFL Week 2 schedule, and they've come away with their best bets for every game.

The tightest spread at the moment is in Rams vs. Cardinals, where the Cardinals are currently just 1-point favorites (-1). The biggest spread is in Raiders vs. Ravens, as Baltimore is an 8.5-point favorite (-8.5) against Las Vegas. The highest over/under is in Bucs vs. Lions at 51.5 points, and the lowest total is the over/under 36.5 in Steelers vs. Broncos.

But those are just the superlatives. Let's get to the Week 2 NFL odds, our expert picks, and NFL predictions for every game.

Week 2 NFL Predictions

NFL Odds for Week 2

  • Chargers vs. Panthers Spread: Chargers -5
  • Saints vs. Cowboys Spread: Cowboys -6
  • Raiders vs. Ravens Spread: Ravens -8.5
  • Bucs vs. Lions Spread: Lions -7.5
  • Jets vs. Titans Spread: Jets -4
  • Seahawks vs. Patriots Spread: Seahawks -3
  • Browns vs. Jaguars Spread: Jaguars -3
  • 49ers vs. Vikings Spread: 49ers -4.5
  • Colts vs. Packers Spread: Colts -2.5
  • Giants vs. Commanders Spread: Commanders -1.5
  • Rams vs. Cardinals Spread: Cardinals -1
  • Bengals vs. Chiefs Spread: Chiefs -6.5
  • Steelers vs. Broncos Spread: Steelers -2.5
  • Sunday Night Football Bears vs. Texans Spread: Texans -6
  • Monday Night Football Falcons vs. Eagles Spread: Eagles -6

Week 2 NFL Schedule

Los Angeles Chargers at Carolina Panthers

Chargers Logo
Sunday, Sep 15
1 p.m. ET
CBS
Panthers Logo
Chargers Odds
SpreadTotalMoneyline
-5
-110
38.5
-110o / -110u
-240
Panthers Odds
SpreadTotalMoneyline
+5
-110
38.5
-110o / -110u
+195
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo
  • Chargers vs. Panthers Spread: Chargers -5
  • Chargers vs. Panthers Over/Under: 38.5 points
  • Chargers vs. Panthers Moneyline: Chargers -240, Panthers +195
  • Chargers vs. Panthers Pick, Prediction: Panthers to cover the spread

New Orleans Saints at Dallas Cowboys

Saints Logo
Sunday, Sep 15
1 p.m. ET
FOX
Cowboys Logo
Saints Odds
SpreadTotalMoneyline
+6
-105
47
-110o / -110u
+235
Cowboys Odds
SpreadTotalMoneyline
-6
-115
47
-110o / -110u
-290
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo
  • Saints vs. Cowboys Spread: Cowboys -6
  • Saints vs. Cowboys Over/Under: 47 points
  • Saints vs. Cowboys Moneyline: Cowboys -290, Saints +235
  • Saints vs. Cowboys Pick, Prediction: Cowboys -19.5 alt spread

Las Vegas Raiders at Baltimore Ravens

Raiders Logo
Sunday, Sep 15
1 p.m. ET
CBS
Ravens Logo
Raiders Odds
SpreadTotalMoneyline
+8.5
-110
41
-110o / -110u
+325
Ravens Odds
SpreadTotalMoneyline
-8.5
-110
41
-110o / -110u
-425
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo
  • Raiders vs. Ravens Spread: Ravens -8.5
  • Raiders vs. Ravens Over/Under: 41 points
  • Raiders vs. Ravens Moneyline: Ravens -425, Raiders +325
  • Raiders vs. Ravens Pick, Prediction: Ravens to cover the spread

Tampa Bay Buccaneers at Detroit Lions

Buccaneers Logo
Sunday, Sep 15
1 p.m. ET
FOX
Lions Logo
Buccaneers Odds
SpreadTotalMoneyline
+7.5
-110
51
-110o / -110u
+300
Lions Odds
SpreadTotalMoneyline
-7.5
-110
51
-110o / -110u
-380
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

New York Jets at Tennessee Titans

Jets Logo
Sunday, Sep 15
1 p.m. ET
CBS
Titans Logo
Jets Odds
SpreadTotalMoneyline
-4
-110
41
-110o / -110u
-200
Titans Odds
SpreadTotalMoneyline
+4
-110
41
-110o / -110u
+165
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo
  • Jets vs. Titans Spread: Jets -4
  • Jets vs. Titans Over/Under: 41 points
  • Jets vs. Titans Moneyline: Jets -200, Titans +165
  • Jets vs. Titans Pick, Prediction: Titans to cover the spread

Seattle Seahawks at New England Patriots

Seahawks Logo
Sunday, Sep 15
1 p.m. ET
FOX
Patriots Logo
Seahawks Odds
SpreadTotalMoneyline
-3
-110
38.5
-110o / -110u
-165
Patriots Odds
SpreadTotalMoneyline
+3
-110
38.5
-110o / -110u
+140
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo
  • Seahawks vs. Patriots Spread: Seahawks -3
  • Seahawks vs. Patriots Over/Under: 38.5 points
  • Seahawks vs. Patriots Moneyline: Seahawks -165, Patriots +140
  • Seahawks vs. Patriots Pick, Prediction: Under

Cleveland Browns at Jacksonville Jaguars

Browns Logo
Sunday, Sep 15
1 p.m. ET
CBS
Jaguars Logo
Browns Odds
SpreadTotalMoneyline
+3
-105
41.5
-110o / -110u
+140
Jaguars Odds
SpreadTotalMoneyline
-3
-115
41.5
-110o / -110u
-165
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo
  • Browns vs. Jaguars Spread: Jaguars -3
  • Browns vs. Jaguars Over/Under: 41.5 points
  • Browns vs. Jaguars Moneyline: Jaguars -165, Browns +140
  • Browns vs. Jaguars Pick, Prediction: Browns to cover the spread

San Francisco 49ers at Minnesota Vikings

49ers Logo
Sunday, Sep 15
1 p.m. ET
CBS
Vikings Logo
49ers Odds
SpreadTotalMoneyline
-4.5
-110
46.5
-110o / -110u
-240
Vikings Odds
SpreadTotalMoneyline
+4.5
-110
46.5
-110o / -110u
+195
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo
  • 49ers vs. Vikings Spread: 49ers -4.5
  • 49ers vs. Vikings Over/Under: 46.5 points
  • 49ers vs. Vikings Moneyline: 49ers -240, Vikings +195
  • 49ers vs. Vikings Pick, Prediction: 49ers to cover the spread

Indianapolis Colts at Green Bay Packers

Colts Logo
Sunday, Sep 15
1 p.m. ET
FOX
Packers Logo
Colts Odds
SpreadTotalMoneyline
-2.5
-105
41
-110o / -110u
-135
Packers Odds
SpreadTotalMoneyline
+2.5
-115
41
-110o / -110u
+115
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo
  • Colts vs. Packers Spread: Colts -2.5
  • Colts vs. Packers Over/Under: 41 points
  • Colts vs. Packers Moneyline: Colts -135, Packers +115
  • Colts vs. Packers Pick, Prediction: Packers to cover the spread

New York Giants at Washington Commanders

Giants Logo
Sunday, Sep 15
1 p.m. ET
FOX
Commanders Logo
Giants Odds
SpreadTotalMoneyline
+1.5
-110
43.5
-110o / -110u
+105
Commanders Odds
SpreadTotalMoneyline
-1.5
-110
43.5
-110o / -110u
-125
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo
  • Giants vs. Commanders Spread: Commanders -1.5
  • Giants vs. Commanders Over/Under: 43.5 points
  • Giants vs. Commanders Moneyline: Commanders -125, Giants +105
  • Giants vs. Commanders Pick, Prediction: Giants moneyline

Los Angeles Rams at Arizona Cardinals

Rams Logo
Sunday, Sep 15
4:05 p.m. ET
FOX
Cardinals Logo
Rams Odds
SpreadTotalMoneyline
+1
-115
48
-110o / -110u
-110
Cardinals Odds
SpreadTotalMoneyline
-1
-105
48
-110o / -110u
-110
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo
  • Rams vs. Cardinals Spread: Cardinals -1
  • Rams vs. Cardinals Over/Under: Cardinals -110, Rams -110
  • Rams vs. Cardinals Moneyline: 48 points
  • Rams vs. Cardinals Pick, Prediction: Rams to cover the spread

Cincinnati Bengals at Kansas City Chiefs

Bengals Logo
Sunday, Sep 15
4:25 p.m. ET
CBS
Chiefs Logo
Bengals Odds
SpreadTotalMoneyline
+6.5
-110
48
-110o / -110u
+235
Chiefs Odds
SpreadTotalMoneyline
-6.5
-110
48
-110o / -110u
-290
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo
  • Bengals vs. Chiefs Spread: Chiefs -6.5
  • Bengals vs. Chiefs Over/Under: 48 points
  • Bengals vs. Chiefs Moneyline: Chiefs -290, Bengals +235
  • Bengals vs. Chiefs Pick, Prediction: Bengals to cover the spread

Pittsburgh Steelers at Denver Broncos

Steelers Logo
Sunday, Sep 15
4:25 p.m. ET
CBS
Broncos Logo
Steelers Odds
SpreadTotalMoneyline
-2.5
-115
36.5
-110o / -110u
-150
Broncos Odds
SpreadTotalMoneyline
+2.5
-105
36.5
-110o / -110u
+125
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo
  • Steelers vs. Broncos Spread: Steelers -2.5
  • Steelers vs. Broncos Over/Under: 36.5 points
  • Steelers vs. Broncos Moneyline: STeelers -150, Broncos +125
  • Steelers vs. Broncos Pick, Prediction: Broncos to cover the spread

Sunday Night Football: Chicago Bears at Houston Texans

Bears Logo
Sunday, Sep 15
8:20 p.m. ET
NBC
Texans Logo
Bears Odds
SpreadTotalMoneyline
+6
-110
45.5
-110o / -110u
+210
Texans Odds
SpreadTotalMoneyline
-6
-110
45.5
-110o / -110u
-260
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo
  • Bears vs. Texans Spread: Texans -6
  • Bears vs. Texans Over/Under: 45.5 points
  • Bears vs. Texans Moneyline: Texans -260, Bears +210
  • Bears vs. Texans Pick, Prediction: Under

Monday Night Football: Atlanta Falcons at Philadelphia Eagles

Falcons Logo
Monday, Sep 16
8:15 p.m. ET
ESPN
Eagles Logo
Falcons Odds
SpreadTotalMoneyline
+6
-110
46.5
-110o / -110u
+210
Eagles Odds
SpreadTotalMoneyline
-6
-110
46.5
-110o / -110u
-260
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo
  • Falcons vs. Eagles Spread: Eagles -6
  • Falcons vs. Eagles Over/Under: 46.5 points
  • Falcons vs. Eagles Moneyline: Eagles -260, Falcons +210
  • Falcons vs. Eagles Pick, Prediction: Under

About the Author
Action Network is a team of seasoned sports betting experts specializing in a broad range of sports, from the NFL and NBA to less mainstream options like cricket and darts. Their staff includes well-known analysts like Sean Koerner and Stuckey, recognized for their accurate predictions and deep sports knowledge. The team is dedicated to delivering expert analysis and daily best bets, ensuring bettors are well-informed across all major sports.

Follow Action Network Staff @ActionNetworkHQ on Twitter/X.

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