Week 5 includes a rematch of last season's NFC Championship Game with the Philadelphia Eagles listed as 3-point home favorites against the Minnesota Vikings.
Also of note are the San Francisco 49ers, who have C.J. Beathard starting for injured Jimmy Garoppolo and are favored by 2.5 points over the Arizona Cardinals.
Here's a full game-by-game rundown for Week 5's matchups.
All numbers as of Tuesday, Sept. 25. Check out Sports Insights for live lookahead lines from Westgate.
Indianapolis Colts at New England Patriots
- Spread: Patriots -8
- Time: 8:20 p.m. ET on Thursday, Oct. 4
- TV: FOX/NFL Network
Baltimore Ravens at Cleveland Browns
- Spread: Ravens -1
- Time: 1 p.m. ET on Sunday, Oct. 7
- TV: CBS
Jacksonville Jaguars at Kansas City Chiefs
- Spread: Chiefs -3.5
- Time: 1 p.m. ET on Sunday, Oct. 7
- TV: CBS
Tennessee Titans at Buffalo Bills
- Spread: Titans -3
- Time: 1 p.m. ET on Sunday, Oct. 7
- TV: CBS
New York Giants at Carolina Panthers
- Spread: Panthers -6
- Time: 1 p.m. ET on Sunday, Oct. 7
- TV: FOX
Denver Broncos at New York Jets
- Spread: Jets -2.5
- Time: 1 p.m. ET on Sunday, Oct. 7
- TV: CBS
Atlanta Falcons at Pittsburgh Steelers
- Spread: Steelers -3
- Time: 1 p.m. ET on Sunday, Oct. 7
- TV: FOX
Green Bay Packers at Detroit Lions
- Spread: Pick'em
- Time: 1 p.m. ET on Sunday, Oct. 7
- TV: FOX
Miami Dolphins at Cincinnati Bengals
- Spread: Bengals -4
- Time: 1 p.m. ET on Sunday, Oct. 7
- TV: CBS
Oakland Raiders at Los Angeles Chargers
- Spread: Chargers -6.5
- Time: 4:05 p.m. ET on Sunday, Oct. 7
- TV: CBS
Arizona Cardinals at San Francisco 49ers
- Spread: 49ers -2.5
- Time: 4:25 p.m. ET on Sunday, Oct. 7
- TV: FOX
Minnesota Vikings at Philadelphia Eagles
- Spread: Eagles -3
- Time: 4:25 p.m. ET on Sunday, Oct. 7
- TV: FOX
Los Angeles Rams at Seattle Seahawks
- Spread: Rams -7
- Time: 4:25 p.m. ET on Sunday, Oct. 7
- TV: FOX
Dallas Cowboys at Houston Texans
- Spread: Texans -4.5
- Time: 8:20 p.m. ET on Sunday, Oct. 7
- TV: NBC
Washington Redskins at New Orleans Saints
- Spread: Saints -7
- Time: 8:15 p.m. ET on Monday, Oct. 8
- TV: ESPN
