Atletico Madrid hosts Real Madrid this Wednesday, March 12, at the Wanda Metropolitano Stadium for the second leg of the Champions League Round of 16. The match kicks off at 4 p.m. ET and will be available on Paramount+.
Real Madrid won the first leg, 2-1, and will aim to secure a ticket to the quarterfinals. Atletico Madrid knows it will face a tough and intense challenge but will try to eliminate the reigning champion from the competition.
Here is my Atletico Madrid vs. Real Madrid prediction and Champions League odds for today's match.
Atletico Madrid vs. Real Madrid Prediction, Pick, Champions League Odds
Atletico Madrid Odds | ||
---|---|---|
Spread | Total | Moneyline |
-0.5 +140 | 2.5 -151o /+117u | +155 |
Real Madrid Odds | ||
---|---|---|
Spread | Total | Moneyline |
+0.5 -151 | 2.5 -151o / +117u | +168 |
- Atletico Madrid vs. Real Madrid moneyline odds: Atletico Madrid +155, Draw +250, Real Madrid +168
- Atletico Madrid vs. Real Madrid over/under: 2.5 Goals (Over -151, Under +117 )
- Atletico Madrid vs. Real Madrid pick: Real Madrid ML | Over 2.5 Goals | Kylian Mbappe Anytime Goalscorer
I am backing Real Madrid ML, Over 2.5 Goals, and Kylian Mbappe Anytime Goalscorer in the Atletico Madrid vs. Real Madrid match.

Atletico Madrid Prediction
Atletico Madrid faces the second leg of the UEFA Champions League Round of 16 with the challenge of overturning the tie after losing 2-1 in the first leg at the Santiago Bernabeu.
Additionally, Diego Simeone's team aims to break a four-game winless streak against Real Madrid and reach the quarte-finals for the second consecutive season. However, they come into this match after a setback in LaLiga, where they lost by the same score against Getafe.
The Metropolitano stands as a key advantage for Atletico, as they have lost only one of their last 14 home games in the Champions League (nine wins and four draws).
In knockout matches of the competition, the team remains unbeaten at home since March 1997, with 11 wins and seven draws. Furthermore, in European clashes at their stadium against Real Madrid, Atletico has suffered just one defeat in seven encounters (three wins and three draws).
Regarding key players, Julián Alvarez has been crucial for Atletico in this Champions League campaign, scoring six goals in the last five matches. His efficiency is remarkable, with eight shots on target in his last seven starts in the competition.
Atletico Madrid relies on its home strength and ability to perform in big matches, aiming to turn the tie around and keep its European dream alive.

Real Madrid Prediction
Real Madrid enters the second leg of the UEFA Champions League Round of 16 with the advantage of a 2-1 victory in the first leg at the Santiago Bernabeu.
Despite the win, coach Carlo Ancelotti remained cautious but acknowledged that the result should boost his team's confidence, especially after their recent 2-1 victory over Rayo Vallecano in LaLiga.
Recent history favors Real Madrid in European knockouts, as they have lost only one of the last 22 ties in which they won the first leg. Under Ancelotti's leadership, the team has successfully advanced in all nine knockout rounds when holding an advantage from the first match.
In European competitions, Real Madrid has shown strong performances away from home, winning their last three Champions League matches on the road and scoring exactly three goals in each. This offensive strength further reinforces their ambitions of reaching the quarterfinals for the fifth consecutive season.
One key player to watch is Brahim Díaz, who has scored after the 50th minute in two of Real Madrid's last three Champions League games. One of those goals was crucial in securing the first-leg victory against Atletico.
With a combination of experience, efficiency in knockouts, and attacking power, Real Madrid aims to close the tie and continue its pursuit of European glory.

Atletico Madrid vs. Real Madrid Pick
Real Madrid enters this match with confidence after winning the first leg and boasting an impeccable record in European knockout rounds when securing an initial advantage. Under Ancelotti, the team has advanced in all nine Champions League ties where they won the first match, proving their ability to close out eliminations effectively. Additionally, Los Blancos have been strong away from home in Europe, winning their last three UCL away games and scoring exactly three goals in each.
The match is expected to be intense, with goals on both sides. In the last 10 Madrid derbies, both teams have found the net, reinforcing the likelihood of an open contest. Ancelotti's squad has demonstrated great attacking efficiency in the Champions League, and with Atletico forced to take risks to overturn the deficit, spaces will likely open up, leading to a high-scoring game.
Kylian Mbappe, one of the world's top players, will be in the starting lineup and will be a key threat to Atletico’s defense. His speed and finishing ability make him the perfect player to exploit any defensive gaps, especially in fast transitions. With Real Madrid's attacking quality and Atletico's need to push forward, Mbappe will have opportunities to score and help secure his team's place in the quarterfinals.