In the first leg of the Round of 16, last season's runner-up, Borussia Dortmund, will face France's Lille with an eye on taking a step closer to the quarterfinals. The match kicks off at 3:00 p.m. ET.
Here is my Borussia Dortmund vs. Lille prediction and Champions League odds for today's match.
Borussia Dortmund vs. Lille Prediction, Pick, Champions League Odds
Borussia Dortmund Odds | ||
---|---|---|
Spread | Total | Moneyline |
-0.5 -137 | 2.5 -129 o / -101 u | -150 |
Lille Odds | ||
---|---|---|
Spread | Total | Moneyline |
+0.5 -111 | 2.5 -129 o / -101 u | +370 |
- Borussia Dortmund vs. Lille moneyline odds: Dortmund -150, Draw +275, Lille +370
- Borussia Dortmund vs. Lille over/under: 2.5 Goals (Over -129, Under -101 )
- Borussia Dortmund vs. Lille pick: Borussia Dortmund Moneyline
I am backing the Borussia Dortmund moneyline in the Borussia Dortmund vs. Lille match.

Borussia Dortmund Prediction
The start of 2025 was a bit chaotic for Borussia Dortmund. The German team went five matches without a win until Niko Kovac took over as the new head coach. Dortmund comes into this match after defeating Sporting Lisbon in the Playoff Round, along with two Bundesliga victories.
Dortmund's scoring ability is something to fear and since Kovac's arrival, their goal average has improved. Before he took charge, the team averaged 1.66 goals per match, but that number has increased to a solid two goals per game (14 goals across seven matches).
If you don't usually follow Borussia Dortmund, one of the key players is Serhou Guirassy. The Guinean striker is Dortmund's top scorer on the season and is averaging a goal per game over his past seven matches.

Lille Prediction
Lille is fifth in France's Ligue 1 and experiencing a rollercoaster season. Their past two matches were against top-tier opponents — a 4-1 defeat to Paris Saint-Germain and a 2-1 win over Monaco. Looking further back, Lille has recorded five wins and five losses in their past 10 games.
This season, Lille has struggled away from home. In their past six away matches, they've won just once, drawn twice and lost three times. Despite those unfavorable stats, the French team has managed to maintain an average of one goal per game.
The Champions League often shifts the context of a team's form, and Lille could be a prime example. While they tend to concede plenty of goals on the road, the French side will travel to Germany looking to grind out a draw and settle the tie on home turf.

Borussia Dortmund vs. Lille Pick
With 22 goals scored, Borussia Dortmund was the second-highest-scoring team in this Champions League's first stage, trailing only Barcelona (28 goals). Despite a managerial change, the German team has maintained its core identity and played well at home.
In seven matches under Kovac's management, Borussia Dortmund has won four, drawn one and lost twice, scoring 14 goals and only conceding four.
Serhou Guirassy leads the team in scoring with 24 goals this season, including 10 in the Champions League, making him the tournament's top scorer.
The first leg between Dortmund and Lille will take place at Signal Iduna Park, the perfect scenario for Borussia Dortmund to extend its Champions League dominance in Germany. That's why I believe the best bet for this match is to back Borussia Dortmund on the moneyline.
If you're looking for a parlay for this match, in addition to betting on Guirassy as an anytime goalscorer, the Over 2.5 Goals market is another solid option. Signal Iduna Park has been synonymous with high-scoring games in this Champions League campaign. So far, five matches have been played there and there have been a total of 18 goals — an average of 3.6 per match.
Borussia Dortmund vs. Lille Pick: Borussia Dortmund Moneyline
Same-Game Parlay for Borussia Dortmund vs. Lille
- Dortmund Moneyline (-150)
- Over 2.5 Goals (-145)
- Serhou Guirassy Anytime Goalscorer (+115)
SGP Payout: +280 — DraftKings