Frances Tiafoe pulled off a stunner in Arthur Ashe Stadium to shake up the landscape of the men's draw in the US Open.
Tiafoe became the first American man to beat Nadal in a major since James Blake accomplished the feat in 2005, and, in the process, he completely rearranged the tournament's futures odds in the process.
Nick Kyrgios was already the favorite following his victory over World No. 1 Daniil Medvedev, but he dipped further toward even money following Nadal's loss.
The Aussie now sits at +175 at FanDuel, while Carlos Alcaraz tails behind at +270. The duo would meet in the final if they were both to win two more matches.
Prior to Nadal's loss, Kyrgios was +200, while Alcaraz was +350. Nadal was slated to fall in Alcaraz's path in the semifinals. Now, if Alcaraz is able to reach that stage of the tournament he would take on Andrey Rublev or Tiafoe.
Jannik Sinner has the third-shortest odds to win his first Grand Slam, listed at +600. Casper Ruud, the French Open finalist who lost to Nadal there earlier this year, is +900.
The aforementioned Tiafoe and Matteo Berrettini, a perennial Slam contender, are both listed at +1300.
Rublev slots in at +1400, and Marin Cilic (+2500), Karen Khachanov (+2900) and Ilya Ivashka (+10000) round out the list of remaining players.
Cilic is the final remaining former Slam champion in the draw. He won the US Open in 2014.
