Orioles vs Nationals Prediction, Parlay, Picks, Odds for Tuesday, April 22

Orioles vs Nationals Prediction, Parlay, Picks, Odds for Tuesday, April 22 article feature image
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Photo Credit: Ron Chenoy-Imagn Images. Pictured: James Wood

The Washington Nationals host the Baltimore Orioles on April 22, 2025. First pitch from Nationals Park is scheduled for 6:45 p.m. EDT; the game will be broadcast on MASN.

Find my Orioles vs Nationals prediction and parlay picks below, as well as probable pitchers, betting trends, injury reports and more.

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My Orioles vs Nationals Parlay Picks

  • Washington Nationals +1.5
  • James Wood 2+ Total Bases
  • Washington Nationals Over 3.5 Total Team Runs

Parlay Odds: +320 at DraftKings


Orioles vs Nationals Odds

Orioles Logo
Tuesday, Apr 22
6:45 p.m. ET
MASN
Nationals Logo
Orioles Odds
SpreadTotalMoneyline
-1.5
+120
9
-105o / -115u
-135
Nationals Odds
SpreadTotalMoneyline
+1.5
-142
9
-105o / -115u
+114
Odds via DraftKings. Get up-to-the-minute MLB odds here.
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Orioles vs Nationals Predictions, Parlay

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Washington Nationals +1.5

The Washington Nationals take on the Baltimore Orioles and are live 'dog, but I’ll gladly take the cheap price on the run line.

Dean Kremer takes the mound for the Orioles and has had some serious control issues this year. On the other side, the Nationals' Mitchell Parker has been very serviceable this year and knows how to keep the ball in the park. Washington also loves to play at its home park, where it is 6-3 this season.

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James Wood 2+ Total Bases

I expect James Wood to start the game with bang tonight. He is a solid candidate to go yard and is becoming one of best leadoff hitters this year. Do not be fooled by his batting average as he has 43 total bases on the year.

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Nationals Over 3.5 Total Runs

The Nationals average over five runs per game at home, so I see a ton of value in backing them against a pitcher who has been struggling. They should be able to put up runs early and knock Kremer out of the game.


Orioles vs Nationals Parlay

  • Washington Nationals +1.5
  • James Wood 2+ Total Bases
  • Washington Nationals Over 3.5 Total Team Runs

Parlay odds: +320 (DraftKings)


Orioles vs Nationals Betting Trends


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About the Author
RB is a seasoned sports handicapper, recognized for his successful betting picks. He collaborates with well-known companies through social media and now contributes his expertise to Action Network. RB leads a VIP team, offering sharp betting analysis to clients. With a Master's in Business Management, he effectively applies his numerical acumen to the gambling industry.

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