The San Diego Padres host the Cleveland Guardians on April 1, 2025. First pitch from PETCO Park is scheduled for 9:40 p.m. EDT; the game will be broadcast on SDPA.
Guardians vs Padres odds have the Padres as -170 moneyline favorites and Guardians as +143 underdogs. The over/under is 7.5 total runs. The Padres are +122 to cover the run line (-1.5) and the Guardians are -145 to cover (+1.5).
Find my Guardians vs Padres predictions and parlay picks for Tuesday night below, as well as probable pitchers, betting trends, injury reports and more.
Guardians vs Padres Predictions
- Guardians vs Padres picks: Padres ML, a Fernando Tatis Jr. Hit and Under 10.5 runs (+158)
My Guardians vs Padres best bets are the Padres moneyline, a Fernando Tatis hit and Under 10.5 runs. Make sure to find the best odds by checking our live MLB odds page.
Guardians vs Padres Odds, Spread, Over/Under
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -144 | 7.5 -110o / -110u | +143 |
| Padres Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +122 | 7.5 -110o / -110u | -170 |
- Guardians vs Padres Moneyline: Guardians +143, Padres -170
- Guardians vs Padres Total: 7.5 (-110o / -110u)
- Guardians vs Padres Run Line: Guardians +1.5 (-144), Padres -1.5 (+122)
- Guardians vs Padres Best Bets: Padres Moneyline; Tatis Hit; Under 10.5
Guardians vs Padres Preview, Prediction, Betting Analysis
In a late-night Tuesday matchup between the Padres and Guardians, we will see Padres' ace Michael King take the mound. I am backing the Padres to win, with Fernando Tatis leading the charge as he goes for his fifth straight game with a hit.
Tonight’s matchup favors the 5-0 Padres for several reasons. To start, King is looking to bounce back from a lackluster season opener in which he pitched just 2 2/3 innings in a 7-4 win against the Braves on Opening Day. I'm confident he'll bounce back.
Additionally, the Padres bats have been performing great, averaging just shy of five runs per game. Specifically, Tatis, Manny Machado and Jackson Merrill all are hitting above .333.
As previously mentioned, Tatis is aiming to extend his hitting streak and I believe he will. Through 20 at-bats this season he has nine hits, three RBI and one home run. Most importantly, however, as the leadoff batter, he has 13 total bases and is proving to be a dominant leadoff hitter.
I'm also backing an alt under. With King on the mound, I see this game being low scoring. Four of the Padres' first five games have gone under 10.5 runs.
Guardians vs Padres Same-Game Parlay
- Padres ML
- Tatis Hit
- Under 10.5
Parlay odds: +180 (Fanatics)
