Baseball fans will be treated to a full, 15-game slate on Friday, April 25.
Between totals, run lines and MLB prop picks, there are numerous betting opportunities to analyze, but our MLB betting experts have already done just that.
So, all that's left for you to do is continue reading. Our MLB best bets for today, Friday, April 25, are below.
MLB Best Bets Today
The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Game | Time (ET) | Pick |
|---|---|---|
  | 2:20 p.m. | |
| 2:20 p.m. | |
  | 6:40 p.m. | |
  | 9:40 p.m. | |
  | 10:05 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
Justin Van Zuiden's Phillies vs Cubs Best Bet: Weather Should Supress Scoring
By Justin Van Zuiden
This is pretty much a weather play for me. Generally, I don't trust Taijuan Walker or Colin Rea, though Rea has been respectable for the Cubs this season.
We have a chilly, damp day in Chicago with the wind blowing in heavily from left field in a park that is very sensitive to the wind. If we had ace pitchers going, the total would be around 5.5 with these conditions.
It is going to be very difficult to get balls in the air to leave the park and despite the talent of these offenses and the struggles of these pitchers, these conditions should keep the scoring in check.
Pick: Under 8 (+100)
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Jim Turvey's Phillies vs Cubs Best Bet: Fade Rea
By Jim Turvey
The Cubs will turn to Colin Rea on Friday in their series opener against the Phillies. Rea has been on a limited pitch count this season and has yet to top 69 pitches, despite some solid outings.
He may see a small jump in pitches tonight as the season progresses, but the Cubs also have a fully rested bullpen and this Phillies' lineup is one you don't want to let see a pitcher too many times.
Speaking of, the Phillies carry the sixth-lowest strikeout rate against right-handed pitchers this season, adding to the appeal of the under here.
Pick: Colin Rea Under 4.5 Strikeouts (-150)
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Justin Van Zuiden's Orioles vs Tigers Best Bet: Trust Mize at Home
By Justin Van Zuiden
Casey Mize was a top draft pick and an elite prospect, but struggled to put things together at the MLB level for a few years. However, he made some strides in 2024 and has had a fantastic start to 2025.
He has allowed zero or one run in three of his four starts and will be pitching at home, in a pitcher-friendly environment, tonight. Meanwhile, Baltimore had to travel after playing in Washington D.C. on Thursday night and got into Detroit at a very late hour.
I trust Mize more than Orioles' rookie Brandon Young and Detroit's offense remains an underrated unit. I'll back the Tigers to get a home win.
Pick: Tigers Moneyline (-118)
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Dead President Picks' Rays vs Padres Best Bet: Padres Rolling in San Diego
The Tampa Bay Rays (11-14) and San Diego Padres (17-8) clash on Friday Night at Petco Park. The Rays, led by Junior Caminero, have won back-to-back games and will send 25-year-old Shane Baz (2-0, 3.22 ERA) to the mound.
