The Cleveland Guardians host the New York Yankees on April 22, 2025. First pitch from Progressive Field is scheduled for 6:10 p.m. EDT; the game will be broadcast on CLEG.
Find my Yankees vs Guardians prediction and same-game parlay picks for Tuesday below.
My Yankees vs Guardians Parlay Picks
- Over 7.5 (-135)
- Anthony Volpe Over 0.5 Hits (-180)
- José Ramírez Over 1.5 Total Bases (+120)
Parlay odds: +375 (Fanatics)
Yankees vs Guardians Odds
| Yankees Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +150 | 8.5 -110o / -110u | -115 |
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -185 | 8.5 -110o / -110u | -105 |
Yankees vs Guardians Projected Starting Pitchers
| RHP Will Warren (NYY) | Stat | RHP Tanner Bibee (CLE) |
|---|---|---|
| 1-0 | W-L | 1-2 |
| 0.1 | fWAR (FanGraphs) | -0.6 |
| 5.17/5.43 | ERA /xERA | 5.85/5.29 |
| 4.38/4.01 | FIP / xFIP | 7.89/5.36 |
| 1.40 | WHIP | 1.50 |
| 10.4 | K-BB% | 4.6 |
| 40.5 | GB% | 45 |
| 103 | Stuff+ | 99 |
| 101 | Location+ | 90 |
Yankees vs Guardians Predictions, Parlay
New York dropped the series opener 6-4 on Monday night, falling to 14-9 on the season.
Despite the loss, the Yankees remain atop the AL East, holding a 1.5-game lead over the Boston Red Sox.
Leading the charge is former MVP Aaron Judge, who’s been scorching hot early in the season, batting .384 with seven home runs and 25 RBIs.
Will Warren will get the start for New York. The right-hander is 1-0 this season with a 5.17 ERA, having allowed nine runs in 15 innings so far.
On the other side, the Guardians enter at 13-9, just a half-game behind the AL Central-leading Detroit Tigers.
Manager Stephen Vogt’s club reached the postseason in two of the last three seasons and made a deep playoff run last year, falling to the Yankees in the ALCS.
Cleveland will turn to Tanner Bibee on the mound. The 25-year-old is 1-2 with a 5.85 ERA and has given up six or more runs in two of his four starts.
At the plate, 24-year-old Kyle Manzardo leads the team with six home runs and 16 RBIs.
Over 7.5 (-135)
Neither starter has found his rhythm early this season.
Bibee has been tagged multiple times, while Warren has also been vulnerable.
With sluggers like Judge, Manzardo, and Ramirez in the mix, I expect these two teams to fly over the 7.5-run total.
Anthony Volpe Over 0.5 Hits (-180)
The Yankees' shortstop has a strong track record against Bibee, going 3-for-6 in his career against the Guardians' right-hander.
Volpe has been seeing the ball well and should stay hot with at least one knock tonight.
José Ramírez Over 1.5 Total Bases (+120)
Cleveland’s veteran slugger is heating up, collecting eight hits in his last six games.
He’s in a favorable spot against Warren and should deliver another multi-base performance.
Yankees vs Guardians Parlay
- Over 7.5 Total Runs
- Anthony Volpe Over 0.5 Hits
- José Ramírez Over 1.5 Total Bases
Parlay odds: +375 (Fanatics)
