Phillies vs Mets Prediction, Picks, Odds for Tuesday, April 22

Phillies vs Mets Prediction, Picks, Odds for Tuesday, April 22 article feature image
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Pictured: Cristopher Sanchez (Credit: Kyle Ross-Imagn Images)

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Matchup - 4/22 11:10pm UTCSpreadTotalMoneyline
-1.5+128
o8-101
-130
+1.5-154
u8-115
+110

The NL East-leading New York Mets (16-7) host the Philadelphia Phillies (13-10) on Tuesday, April 22. First pitch from Citi Field is scheduled for 7:10 p.m. ET; the game will be broadcast on TBS.

After New York's offense broke out with some big blows against Philly in the first game of this series on Monday, it may be time for the Phillies to return the favor with an edge in Tuesday's pitching matchup.

Find my Phillies vs Mets prediction below, as well as probable pitchers, betting trends, weather forecast and more.

Quickslip

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Phillies vs Mets Prediction

  • Phillies vs Mets pick: Phillies Moneyline -132 (Play to -140)

My Phillies vs Mets best bet is Phillies moneyline. Make sure to find the best odds by checking our live MLB odds page.


Phillies vs Mets Odds

Philadelphia Phillies Logo
Tuesday, April 22
7:10 p.m. ET
TBS
New York Mets Logo
Philadelphia Phillies Odds
SpreadTotalMoneyline
-1.5
+125
8
-105o / -115u
-130
New York Mets Odds
SpreadTotalMoneyline
+1.5
-150
8
-105o / -115u
+110
Odds via BetMGM. Get up-to-the-minute MLB odds here.
BetMGM Logo
  • Phillies vs Mets Moneyline: Phillies -130, Mets +110
  • Phillies vs Mets Total: 8 (-105o / -115u)
  • Phillies vs Mets Run Line: Phillies -1.5 (+125), Mets +1.5 (-150

Phillies vs Mets Projected Starting Pitchers

LHP Cristopher Sanchez (PHI)StatRHP Griffin Canning (NYM)
2-0W-L2-1
0.4fWAR (FanGraphs)0.3
2.96/2.65ERA /xERA3.43/3.88
3.61/2.55FIP / xFIP3.71/3.64
1.15WHIP1.33
24.8K-BB%12.5
53.2GB%53.6
116Stuff+91
101Location+102

Ducey’s Phillies vs Mets Preview

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Phillies Betting Preview: Look to Rebound Behind Sanchez

It's hard to call Cristopher Sanchez a late bloomer at 28 years old, particularly after two strong seasons in Philly's rotation, but he's begun to make a leap into ace territory this year.

Sanchez has remained a ground-ball forward arm, but he's traded in some of those worm-burners for more strikeouts, with a 30.7% K-rate through four starts to put him into that elite tier.

The lefty has also managed a .215 Expected Batting Average — which is well below his roughly average .249 xBA over his career — and the xSLG has come down almost 40 points from a very strong .362 in 2024.

As he continues limiting walks and pitching to friendly contact, there aren't many great ways to score off the lefty right now. His sinker has actually been hit 30 points better than expected, too, largely due to the Phillies sitting 15th in Outs Above Average in the infield.

They did rank 13th last year and retain some good personnel, so there's a chance Sanchez could further improve on his earth-shattering early results.


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Mets Betting Preview: Ride Momentum at Citi Field

The Mets are getting good innings from one of their newest pitching-factory projects in Griffin Canning, who owns a 3.43 ERA through his first 21 innings in New York.

He's been a fellow ground-ball producer, rolling them up at a 54.4% clip, though with the Mets' infield ranking 20th in OAA, there are certainly some concerns that he'll be able to sustain such friendly numbers.

Still, there's not a whole lot to hate about the start. His .247 xBA and 3.88 xERA are right around the league average, and he's regained his strikeout touch at a 23.9% clip thus far.

Canning has never been a maestro when it comes to limiting walks, however, and his 11.4% walk rate currently stands as the worst of his career.

Limiting walks and hard-hit balls will be key for Canning, who's been prone to giving up homers in the past with his contact-oriented approach. Dfense will also be of the utmost importance for a Mets unit that's looked challenged in all areas of the field.

There's also a chance that Jesse Winker — who drove the ship offensively on Monday — will be held out in favor of Starling Marte as part of this team's outfield platoon, which would certainly give me a bit less faith in this team to hit the ball.


Phillies vs Mets Prediction, Betting Analysis

So far, the Phillies have looked like a sound team at the plate. They struck out a surprising 10 times against Tylor Megill, but overall this season, they own a friendly 11.3% walk rate and 21.6% strikeout rate to rank among the most disciplined teams in the league.

Power has abandoned them, but they've hit .251 and should stand a great chance at getting to Canning in this one.

The Mets may make a platoon switch, which hurts them at the plate. With their heavy reliance on power hitting, I'm not quite sure that's one that makes sense. New York is just 23rd in OPS to ground-ballers this year, too, which is five spots lower than its ranking against fly-ball arms.

Considering they struggle against ground-ballers, own just a 91 wRC+ against lefties and struggle with strikeouts in that split, I'm very confident that Sanchez will perform in this one and lead Philly to a big win.

He may not need much run support, but he should get some with Canning sitting in a vulnerable position.

Pick: Phillies ML -132 (Play to -140)


Moneyline

The sharps are hitting the Phillies on the moneyline here, and while 53% of the bets are on the road favorites, they've accounted for even more of the handle at 57%.


Run Line (Spread)

The Phillies have gone 7-2 to the run line after a loss this season, while the Mets are 7-8 after a win.


Over/Under

The sharp money and our experts are on the under here, and I like that bet almost as much as the Phillies on the moneyline. The under is a perfect 5-0 when the Mets have been underdogs this year.


Phillies vs Mets Betting Trends


Phillies vs Mets Weather


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About the Author
Kenny Ducey, a leading voice in tennis betting and MLB handicapping, has built an online following through his work for Tennis Channel and his background in baseball reporting for Sports Illustrated and Baseball Prospectus. With over a decade of experience, including covering the New York Knicks and Yankees for Fordham's WFUV Radio, Ducey writes betting previews for Action Network and contributes digitally to Tennis Channel, having also worked for NBC Sports and DraftKings.

Follow Kenny Ducey @kennyducey on Twitter/X.

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