The Clemson Tigers take on the Louisville Cardinals in the ACC Tournament. Tip-off is set for 9:30 p.m. ET on ESPN.
Clemson is favored by 1 point on the spread with a moneyline of -120. The total is set at 141.5 points.
Here are my Clemson vs. Louisville predictions and college basketball picks for March 14, 2025.
Clemson vs Louisville Prediction
My Pick: Clemson ML -120
My Clemson vs Louisville best bet is on Clemson to win the game outright, with the best odds currently available at FanDuel. For all of your college basketball bets, be sure to find the best lines by using our live NCAAB odds page.
Clemson vs Louisville Odds
| Clemson Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1 -112 | 141.5 -112o / -108u | -120 |
| Louisville Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1 -108 | 141.5 -112o / -108u | +100 |
- Clemson vs Louisville spread: Clemson -1 (-112), Louisville +1 (-108)
- Clemson vs Louisville over/under: 141.5 (-112o / -108u)
- Clemson vs Louisville moneyline: Clemson -120, Louisville +100
- Clemson vs Louisville best bet: Clemson ML -120
Spread
I'm betting the Tigers in this game, but I prefer taking them on the moneyline as opposed to the spread.
Moneyline
My best bet for this Friday ACC Tournament game is for Clemson to beat Louisville outright.
Over/Under
I don't have a bet on the total in this game.
My Pick: Clemson ML -120
Clemson vs Louisville College Basketball Betting Preview
The ACC Tournament semifinals are here! On one side of the bracket, North Carolina faces off against Duke, and on the other side, Clemson takes on Louisville.
Clemson and Louisville played on Jan. 7 when the Cardinals won, 74-64, on their home floor. Louisville’s J’Vonne Hadley had a career day, dropping 32 points while shooting 10-of-12 from the floor.
Overall, this was a wire-to-wire win, as the Cardinals were up seven at halftime and did not look back. Louisville was favored by 3.5 points and covered with ease.
Now, Clemson is coming into this game with a nine-game winning streak. Although the Tigers are hot, they're also looking for redemption against Louisville.
Clemson hasn't been to the ACC Tournament Championship since 2008, and I think that changes after tonight’s matchup.
The Tigers are a better defensive team, and they play at a slow pace. That's going to cause problems for Pat Kelsey's Louisville team, which likes to get out and run.
If Clemson can get stops on the defensive end and defend the 3-point line, I think this team has a chance of doing something special. The Tigers play solid defense and are great at not fouling.
Expect to see Brad Brownell’s team fired up tonight and doing the little things right. Don’t be surprised if Clemson wins by 6-plus in this low-scoring defensive battle tonight in Charlotte.
Take Clemson moneyline — let’s cash!
