Today, we'll dial up a three-game parlay for a loaded Saturday college basketball slate.
We'll begin this parlay in the Atlantic 10 for a matchup between the Saint Joseph’s Hawks and the George Mason Patriots.
Then, we'll head to the ACC Championship for the second leg of this parlay. The Duke Blue Devils and the Louisville Cardinals will battle things out on Saturday.
Finally, we'll go to Henderson, Nevada, for the last leg of this parlay. UC Irvine and UC San Diego will clash with a March Madness berth at stake.
College Basketball Parlay for Saturday, March 15
With the matchups set, let's dive into my college basketball parlay and NCAAB predictions for Saturday, March 15.
College Basketball Picks, Parlay
- Saint Joe's ML -120 vs. George Mason
- Louisville +5.5 vs. Duke
- UC San Diego ML -265 vs. UC Irvine
Parlay Odds: +400 via DraftKings
Remember that some parlays are long shots for a reason, so please bet responsibly.

Saint Joseph ML -120
3:30 p.m. ET · CBS Sports Network
Saint Joseph’s comes into the matchup with a record of 22-11. The Hawks are coming off a thrilling win last night over the Dayton Flyers. The Hawks led early in the game, but the Flyers' late run opened up a four-point lead with less than a minute to go.
Saint Joe's fought back late with multiple stops to force overtime. The Hawks were the better team in the last five minutes, winning 73-68 in overtime. Philadelphia native Xzayvier Brown leads the Hawks with 17.2 points per game.
George Mason posted a strong record of 25-7, which placed the Patriots second in the conference. George Mason's 15-3 record was tied with VCU for the best record in the A-10.
The Patriots are coming off an 80-65 win over George Washington. Senior Jalen Hayes leads the team with 13.8 points per game.
Despite being the lower seed, we see the Hawks as a slight favorite in this contest. Their pace will be problematic for this Patriots team. The Hawks rank 127th in points per game compared to George Mason, which ranks 260th.

Louisville +5.5 (-102)
8:30 p.m. ET · ESPN
Duke rolls into the contest with a record of 30-3 and the No. 1 overall ranking in the country. The Blue Devils survived a last-minute disaster last night against North Carolina.
Duke will be playing without its superstar Copper Flagg tonight. Flagg leads the Blue Devils with 18.9 points, 7.5 rebounds and 4.1 assists per game.
Lousiville has a record of 27-6, with the Cardinals ranked 13th in the nation. First-year head coach Pat Kelsey has done an outstanding job with this program, which hasn't gone dancing since 2019. Wisconsin transfer Chucky Hepburn leads the team with 16.3 points per game.
We'll ride with the underdog in this matchup. Duke showed last night that it has flaws closing games with Flagg out of the lineup.
The Cardinals are a gritty team that will compete for 40 minutes on both sides of the ball and cause matchup issues throughout the night.

UC San Diego ML -265
9:30 p.m. ET · ESPN2
UC Irvine has a record of 28-5 on the season and 17-3 in the Big West. That record placed the Anteaters second in the conference. Irvine has won six consecutive games, and its last loss was against UC San Diego on February 8.
Big man Bent Leuchten leads the team with 15.6 points and 9.1 rebounds.
UC San Diego has a record of 29-4. Many people believe that UC San Diego will dance on Sunday night regardless of tonight’s result. The Tritons have won 14 consecutive games. Aniwaniwa Tait-Jones leads the team with 19.7 points per game.
We'll trust the heavy favorite to close this parlay. The Tritons are as hot as anyone in college basketball right now and will lock up a berth in the Big Dance tonight.
UC San Diego ranks sixth in the nation in defense. The Tritons' ability to slow down the Anteaters will be the difference in a win tonight.